ArticleWorld journal of gastroenterology2006
Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of Postoperative Gum Chewing on Recovery of Gastrointestinal Function Following Laparoscopic Gynecologic Surgery: Systematic Review and Meta-Analysis of Prospective StudiesJournal of clinical medicine · 2024Review
- Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea.Nutrients · 2021Article
- Unsuspecting Dietary Factors in Hyperkalemia: A Case Report on Why History Matters.Clinical practice and cases in emergency medicine · 2020Article
- Sorbitol: Often forgotten cause of osmotic diarrhea.Canadian family physician Medecin de famille canadien · 2019Article
- Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Identification of differential metabolites in liquid diet fermented withAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2016Article
- Myo-inositol inhibits intestinal glucose absorption and promotes muscle glucose uptake: a dual approach study.Journal of physiology and biochemistry · 2016Article
- Impact of excipient interactions on drug bioavailability from solid dosage forms.Pharmaceutical research · 2012Review
- Carbohydrate malabsorption in patients with non-specific abdominal complaints.World journal of gastroenterology · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the possible causes of sorbitol (S)-based diarrhea and its mechanism of reduction by rice gruel (RG) in cecectomized rats.
methodsS was dissolved either in distilled water or in RG (50 g/L) and ingested as a single oral dose (1.2 g/kg body mass, containing 0.5 g/L phenol red as a recovery marker) by S (control) and S + RG groups (n = 7), respectively. This dose is over the laxative dose for humans. Animals were sacrificed exactly 1 h after dose ingestion, without any access to drinking water. The whole gastro-intestinal tract was divided into seven segments and sampled to analyze the S and marker remaining in its contents.
resultsGastric-emptying and intestinal transit were comparatively slower in the S + RG group. Also, the S absorption index in the 3(rd) and last quarter of the small intestine (24.85 +/- 18.88% vs 0.0 +/- 0.0% and 39.09 +/- 32.75% vs 0.0 +/- 0.0%, respectively, P < 0.05) was significantly higher in the S + RG group than in the control group. The S absorption index and the intestinal fluid volume are inversely related to each other.
conclusionThe intestinal mal-absorption of S is the main reason for S-based osmotic diarrhea. Where RG enhanced the absorption of S through passive diffusion, the degree of diarrhea was reduced in cecectomized rats.
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