ArticleWorld journal of gastroenterology2006
New multi protein patterns differentiate liver fibrosis stages and hepatocellular carcinoma in chronic hepatitis C serum samples.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Top-Down Proteomics Identifies Plasma Proteoform Signatures of Liver Cirrhosis Progression.Molecular & cellular proteomics : MCP · 2024Article
- Differences in HDL-Bound Apolipoproteins in Patients With Advanced Liver Fibrosis Due to Nonalcoholic Fatty Liver Disease.The Journal of clinical endocrinology and metabolism · 2022Article
- Proteomic Profiling of Liver and Plasma in Chronic Ethanol Feeding Model of Hepatic Alcohol Dehydrogenase-Deficient Deer Mice.Alcoholism, clinical and experimental research · 2017Article
- Identification of apolipoprotein C-I as a potential Wilms' tumor marker after excluding inflammatory factors.International journal of molecular sciences · 2014Article
- Serum biomarkers identification by mass spectrometry in high-mortality tumors.International journal of proteomics · 2013Article
- Genomics and proteomics in liver fibrosis and cirrhosis.Fibrogenesis & tissue repair · 2012Article
- A novel "reactomics" approach for cancer diagnostics.Sensors (Basel, Switzerland) · 2012Article
- Towards noninvasive detection of oesophageal varices.International journal of hepatology · 2012Article
- From proteomic multimarker profiling to interesting proteins: thymosin-β(4) and kininogen-1 as new potential biomarkers for inflammatory hepatic lesions.Journal of cellular and molecular medicine · 2011Article
- Plasma biomarker screening for liver fibrosis with the N-terminal isotope tagging strategy.Science China. Life sciences · 2011Article
- Article
- Clinical proteomics for liver disease: a promising approach for discovery of novel biomarkers.Proteome science · 2010Article
- Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease.Hepatology (Baltimore, Md.) · 2010Article
- The current state of proteomics in GI oncology.Digestive diseases and sciences · 2009Review
- Proteomic analysis of HCV cirrhosis and HCV-induced HCC: identifying biomarkers for monitoring HCV-cirrhotic patients awaiting liver transplantation.Transplantation · 2009Article
- Detection of Colorectal Cancer by Serum and Tissue Protein Profiling: A Prospective Study in a Population at Risk.Biomarker insights · 2008Article
- Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients.World journal of gastroenterology · 2008Article
- Expression and clinical significance of NET-1 and PCNA in hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2008Article
- Mass spectrometry based proteomics in urine biomarker discovery.World journal of urology · 2007Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify a multi serum protein pattern as well as single protein markers using surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF-MS) for detection and differentiation of liver fibrosis (F1-F2), liver cirrhosis (F4) and hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV).
methodsSerum samples of 39 patients with F1/F2 fibrosis, 44 patients with F4 fibrosis, 34 patients with HCC were applied to CM10 arrays and analyzed using the SELDI-TOF ProteinChip System (PBS-IIc; Ciphergen Biosystems) after anion-exchange fractionation. All patients had chronic hepatitis C and histologically confirmed fibrosis stage/HCC. Data were analyzed for protein patterns by multivariate statistical techniques and artificial neural networks.
resultsA 4 peptide/protein multimarker panel (7486, 12,843, 44,293 and 53,598 Da) correctly identified HCCs with a sensitivity of 100% and specificity of 85% in a two way-comparison of HCV-cirrhosis versus HCV-HCC training samples (AUROC 0.943). Sensitivity and specificity for identification of HCC were 68% and 80% for random test samples. Cirrhotic patients could be discriminated against patients with F1 or F2 fibrosis using a 5 peptide/protein multimarker pattern (2873, 6646, 7775, 10,525 and 67,867 Da) with a specificity of 100% and a sensitivity of 85% in training samples (AUROC 0.976) and a sensitivity and specificity of 80% and 67% for random test samples. Combination of the biomarker classifiers with APRI score and alfa-fetopotein (AFP) improved the diagnostic performance. The 6646 Da marker protein for liver fibrosis was identified as apolipoprotein C-I.
conclusionSELDI-TOF-MS technology combined with protein pattern analysis seems a valuable approach for the identification of liver cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis C. Most probably a combination of different serum markers will help to identify liver cirrhosis and early-stage hepatocellular carcinomas in the future.
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