ArticleHuman genetics2007
High-resolution mapping identifies a commonly amplified 11q13.3 region containing multiple genes flanked by segmental duplications.
Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- LTO1 and YAE1 regulate MHC-I expression via nonsense-mediated RNA decay in tumor cells.Journal for immunotherapy of cancer · 2025Article
- Copy number alterations identify a smoking-associated expression signature predictive of poor outcome in head and neck squamous cell carcinoma.Cancer genetics · 2021Article
- The Identification of the Metabolism Subtypes of Skin Cutaneous Melanoma Associated With the Tumor Microenvironment and the Immunotherapy.Frontiers in cell and developmental biology · 2021Article
- The EMSY Gene Collaborates with CCND1 in Non-Small Cell Lung Carcinogenesis.International journal of medical sciences · 2017Article
- Article
- FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion.Oncology research · 2016Article
- Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss.Genes, chromosomes & cancer · 2014Article
- Heterogeneity of 11q13 region rearrangements in laryngeal squamous cell carcinoma analyzed by microarray platforms and fluorescence in situ hybridization.Molecular biology reports · 2013Article
- A common copy-number breakpoint of ERBB2 amplification in breast cancer colocalizes with a complex block of segmental duplications.Breast cancer research : BCR · 2012Article
- Article
- Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases.Molecular cancer therapeutics · 2011Article
- Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening.Cancer cell · 2011Article
- T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy.Blood · 2011Article
- Strategies to promote translational research within the European Organisation for Research and Treatment of Cancer (EORTC) Head and Neck Cancer Group: a report from the Translational Research Subcommittee.Annals of oncology : official journal of the European Society for Medical Oncology · 2010Review
- Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure.Genome research · 2010Article
- ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines.British journal of cancer · 2010Article
- Genomic segmental duplications on the basis of the t(9;22) rearrangement in chronic myeloid leukemia.Oncogene · 2010Article
- Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.Oral oncology · 2008Review
- Cortactin expression predicts poor survival in laryngeal carcinoma.British journal of cancer · 2008Article
- Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor status.British journal of cancer · 2008Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA amplification of the 11q13 region is observed frequently in many carcinomas. Within the amplified region several candidate oncogenes have been mapped, including cyclin D1, TAOS1 and cortactin. Yet, it is unknown which gene(s) is/are responsible for the selective pressure enabling amplicon formation. This is probably due to the use of low-resolution detection methods. Furthermore, the size and structure of the amplified 11q13 region is complex and consists of multiple amplicon cores that differ between different tumor types. We set out to test whether the borders of the 11q13 amplicon are restricted to regions that enable DNA breakage and subsequent amplification. A high-resolution array of the 11q13 region was generated to study the structure of the 11q13 amplicon and analyzed 29 laryngeal and pharyngeal carcinomas and nine cell lines with 11q13 amplification. We found that boundaries of the commonly amplified region were restricted to four segments. Three boundaries coincided with a syntenic breakpoint. Such regions have been suggested to be putatively fragile. Sequence comparisons revealed that the amplicon was flanked by two large low copy repeats known as segmental duplications. These segmental duplications might be responsible for the typical structure and size of the 11q13 amplicon. We hypothesize that the selection for genes through amplification of the 11q13.3 region is determined by the ability to form DNA breaks within specific regions and, consequently, results in large amplicons containing multiple genes.
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