ArticleWorld journal of surgery2007
Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection.
Article in World journal of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Review of the investigation and surgical management of resectable ampullary adenocarcinoma.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2013Pooled it
- Intraoperative allogeneic red blood cell transfusion in ampullary cancer outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis.World journal of surgery · 2008Pooled it
- Metallic or plastic stent for bile duct obstruction in ampullary cancer?Digestive diseases and sciences · 2012Trial
- Histopathologic Subtype as a Determinant of Prognosis and Chemotherapy Benefit in Resected Ampullary Adenocarcinoma.Journal of hepato-biliary-pancreatic sciences · 2026Article
- Association Between Tumor-Infiltrating Immune Cells and Early Recurrence in Ampulla of Vater Carcinoma.Cureus · 2025Article
- The Prognostic Significance of the CALLY Index in Ampullary Carcinoma: An Inflammation-Nutrition Retrospective Analysis.Journal of inflammation research · 2025Article
- Clinicopathologic Analysis and Prognostic Factors for Survival in Patients with Operable Ampullary Carcinoma: A Multi-Institutional Retrospective Experience.Medicina (Kaunas, Lithuania) · 2024Article
- Expression Profile of KRAS and p16 in Periampullary Cancer.Indian journal of surgical oncology · 2024Article
- Clinical impact of ampulla of Vater cancer subtype classification based on immunohistochemical staining.World journal of surgical oncology · 2024Article
- Article
- Predictors and Recurrence Patterns After Radical Surgery in Ampulla of Vater Cancer: Comparative Analysis Between Early and Late Recurrence.Frontiers in surgery · 2022Article
- Treatment Approach to Adenocarcinoma of the Ampulla of Vater.Current treatment options in oncology · 2021Review
- Clinicopathological Prognostic Factors and Chemotherapeutic Outcome for Two Histopathological Types of Ampulla of Vater Adenocarcinoma.Frontiers in oncology · 2021Article
- Choice of surgical procedures for patients with stage T1 carcinoma of the papilla of Vater: a retrospective study.Translational cancer research · 2020Article
- Predictors of early recurrence following a curative resection in patients with a carcinoma of the ampulla of Vater.Annals of surgical treatment and research · 2020Article
- Genetic Alterations of Periampullary and Pancreatic Ductal Adenocarcinoma: An Overview.Current genomics · 2018Review
- Prognostic role of neutrophil-to-lymphocyte ratio (NLR) in patients with operable ampullary carcinoma.Bosnian journal of basic medical sciences · 2018Article
- Determining the Adequate Examined Lymph Node Count in Resected Ampullary Adenocarcinoma-A National Cohort Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- Endoscopic papillectomy of benign ampullary lesions: Outcomes from a multicenter study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Relationship between mismatch repair immunophenotype and long-term survival in patients with resected periampullary adenocarcinoma.Journal of translational medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe prognosis for patients with carcinoma of the ampulla of Vater is improved relative to other periampullary neoplasms. Identification of independent prognostic factors in ampullary carcinomas has been limited by the small number of tumors resected. The aim of the present study was to determine the clinicopathologic factors that influence long-term survival in patients with resected ampullary carcinoma.
methodsClinicopathologic data were retrospectively reviewed for patients with ampullary carcinomas radically resected between March 1987 and September 2002. The correlation between clinicopathologic variables and survival of patients after resection was examined by the Kaplan-Meier method, the log-rank test, and Cox proportional hazards regression. Ampullary carcinomas were radically resected in 127 patients either by pancreaticoduodenectomy (n = 124) or local resection (n = 3).
resultsHospital mortality was 9.7%. The overall actuarial survival rates (including hospital deaths) at 1, 3, 5, and 10 years were 76.2%, 46.8%, 43.3%, and 35.7%, respectively. Factors that significantly influenced survival were lymph node status (P < 0.001), depth of tumor infiltration (P = 0.029), and TNM stage (P < 0.001) on univariate analysis. On multivariate analysis, both depth of infiltration and lymph node status were the independent determinants of survival after resection (P = 0.003, P = 0.005, respectively).
conclusionsCarcinoma of the ampulla of Vater has a higher resectability rate and a much better survival rate than pancreatic cancer. Pancreaticoduodenectomy is the treatment of choice for this tumor. Long-term survival was independently influenced by the depth of tumor infiltration and lymph node metastasis.
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