Evidence map›Paper›PMID 17171451›Full record

ArticleDigestive diseases and sciences2007

Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer.

Ikuko Kato, Federico Canzian, Martyn Plummer, Silvia Franceschi, Leen-Jan van Doorn, Jorge Vivas, Gladys Lopez, Yanhui Lu, Lydie Gioia-Patricola, Richard K Severson and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Positive association between Toll-like receptor 4 gene +896A/G polymorphism and susceptibility to gastric carcinogenesis: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
    Pooled it
  3. Article
  4. Effect ofExperimental and therapeutic medicine · 2015
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. TLR4 polymorphisms and disease susceptibility.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012
    Review
  10. Article
  11. Review
  12. CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2009
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Ikuko KatoKarmanos Cancer Institute, 110 East Warren Avenue, Detroit, Michigan 48201, USA. katoi@med.wayne.edu
Federico Canzian
Martyn Plummer
Silvia Franceschi
Leen-Jan van Doorn
Jorge Vivas
Gladys Lopez
Yanhui Lu
Lydie Gioia-Patricola
Richard K Severson
Ann G Schwartz
Nubia Muñoz
Centre International de Recherche sur le Cancer · FRUniversidad Nacional Experimental del Táchira · VEWayne State University · USDDL Diagnostic Laboratory · NLThe Barbara Ann Karmanos Cancer Institute · US

Funding

Genetic Susceptibility to Infection Related CancerR01CA098309 · NCI · WAYNE STATE UNIVERSITY · PI KATO, IKUKO · 2003 to 2005
$609k
NCI NIH HHS CA 98309
6 · The paper itself

Abstract

As Helicobacter pylori (HP) is a Gram-negative bacterium, we investigated the associations between several functional polymorphisms in genes involved in lipopolysaccharide (LPS) signaling and the prevalence of various stages of gastric premalignant lesions in a Venezuelan population. The two NOD2 polymorphisms, del3020insC and Gly908Arg, were too infrequent to study their associations with gastric lesions. The risk of intestinal metaplasia (IM) was significantly increased among subjects with the CD14 T-260 allele compared to those without this allele. A similar, but nonsignificant increase in risk for dysplasia was observed among homozygotes of this allele. There was no association between TLR4 Asp299Gly polymorphism and any type of lesions, except for a slight nonsignificant increase in risk of IM associated with the AA genotype among subjects with a higher histological HP score. These results suggest that genetic polymorphisms in HP LPS signaling may be implicated in the development of intermediate stages of gastric premalignant lesions.

Indexed as

Polymorphism, GeneticAdultFemaleGastroscopyGenotypeHelicobacter InfectionsHelicobacter pyloriHumansLipopolysaccharide ReceptorsLipopolysaccharidesMaleMiddle AgedNod2 Signaling Adaptor ProteinPeptidoglycanPrecancerous ConditionsStomach NeoplasmsLipopolysaccharide ReceptorsLipopolysaccharidesNOD2 protein, humanNod2 Signaling Adaptor ProteinPeptidoglycanTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID17171451
OpenAlexW2091708644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.