ArticleNaunyn-Schmiedeberg's archives of pharmacology2007
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Intra-articular use of radium dichloride ([European journal of nuclear medicine and molecular imaging · 2021Article
- Article
- Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation.Inflammopharmacology · 2020Article
- Structure determination of the human TRPV1 ankyrin-repeat domain under nonreducing conditions.Acta crystallographica. Section F, Structural biology communications · 2020Article
- Effect of certain trimethoxy flavones on paclitaxel - induced peripheral neuropathy in mice.Integrative medicine research · 2018Article
- Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification.The Journal of biological chemistry · 2016Article
- Protective effect of low-level laser therapy (LLLT) on acute zymosan-induced arthritis.Lasers in medical science · 2014Article
- Anti-inflammatory and immunomodulatory effect of an extract of Coccidioides posadasii in experimental arthritis.Mycopathologia · 2013Article
- Roles of reactive oxygen and nitrogen species in pain.Free radical biology & medicine · 2011Review
- Tadalafil analgesia in experimental arthritis involves suppression of intra-articular TNF release.British journal of pharmacology · 2011Article
- Experimental model of zymosan-induced arthritis in the rat temporomandibular joint: role of nitric oxide and neutrophils.Journal of biomedicine & biotechnology · 2011Article
- Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance.Neuroscience letters · 2010Article
- Article
- Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance.Neuroscience · 2009Article
- Peroxynitrite and opiate antinociceptive tolerance: a painful reality.Archives of biochemistry and biophysics · 2009Review
- Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.Free radical biology & medicine · 2009Article
- Protective effect of an extract from Ascaris suum in experimental arthritis models.Infection and immunity · 2008Article
- Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice.British journal of pharmacology · 2008Article
- The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF-alpha and PGE2-dependent mechanisms.British journal of pharmacology · 2007Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the contribution of neutrophils to joint hyperalgesia and peroxynitrite formation in zymosan arthritis. Rats received 1 mg zymosan intra-articular, and joint hyperalgesia was measured using the rat knee-joint articular incapacitation test. After 6 h, joint exudates were collected by aspiration for the assessment of cell influx, myeloperoxidase activity, and nitrite (as an index of nitric oxide formation) levels. Nitrotyrosine content, used as an index of peroxynitrite formation, was measured in joint exudates, using enzyme-linked immunosorbent assay. A group of rats was rendered neutropenic through the administration of a rabbit anti-rat neutrophil antibody (2 ml kg(-1), i.p.) 30 min before injection of 1 mg zymosan intra-articular. Other groups received uric acid (100 or 250 mg kg(-1), i.p.), the peroxynitrite scavenger, 30 min before 1 mg zymosan intra-articular. Controls received the vehicle. The significant inhibition of joint hyperalgesia in neutropenic animals was associated to significantly decreased cell influx, myeloperoxidase activity, nitric oxide, and nitrotyrosine levels in the joint exudates, as compared to naive rats. Uric acid administration inhibited both hyperalgesia and cell influx, as compared to controls. Neutrophils are involved in both nitric oxide and peroxynitrite formation in zymosan arthritis, thereby contributing to acute joint hyperalgesia. Scavenging of reactive nitrogen species (e.g. peroxynitrite) inhibits neutrophil migration and joint hyperalgesia in the acute phase of zymosan arthritis in rats.
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