ReviewDie Naturwissenschaften2007
Behavioral genomics of honeybee foraging and nest defense.
Review in Die Naturwissenschaften, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 207 citations in OpenAlex.
- Article
- Hangry bees: Pollen dearth impacts honey bee (Apis mellifera) behavior and physiology.PloS one · 2026Article
- Top-Down Coercive Mechanisms and the Major Transitions in Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
- Tyramine and itseLife · 2023Article
- Identifying a developmental transition in honey bees using gene expression data.PLoS computational biology · 2023Article
- Single-cell dissection of aggression in honeybee colonies.Nature ecology & evolution · 2023Article
- Article
- Explaining workers' inactivity in social colonies from first principles.Journal of the Royal Society, Interface · 2023Article
- Honey compositional convergence and the parallel domestication of social bees.Scientific reports · 2022Article
- Genes associated with hot defensive bee ball in the Japanese honeybee, Apis cerana japonica.BMC ecology and evolution · 2022Article
- Opposing Actions of Octopamine and Tyramine on Honeybee Vision.Biomolecules · 2021Article
- Societies to genes: can we get there from here?Genetics · 2021Article
- Identification of quantitative trait loci associated with calmness and gentleness in honey bees using whole-genome sequences.Animal genetics · 2021Article
- Tachykinin signaling inhibits task-specific behavioral responsiveness in honeybee workers.eLife · 2021Article
- Search Behavior of Individual Foragers Involves Neurotransmitter Systems Characteristic for Social Scouting.Frontiers in insect science · 2021Article
- Selection and hybridization shaped the rapid spread of African honey bee ancestry in the Americas.PLoS genetics · 2020Article
- Defense Response in Brazilian Honey Bees (Apis mellifera scutellata × spp.) Is Underpinned by Complex Patterns of Admixture.Genome biology and evolution · 2020Article
- Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Screening and Validation of Reference Genes for RT-qPCR Under Different Honey Bee Viral Infections and dsRNA Treatment.Frontiers in microbiology · 2020Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 4 countries.
Funding
Abstract
The honeybee has been the most important insect species for study of social behavior. The recently released draft genomic sequence for the bee will accelerate honeybee behavioral genetics. Although we lack sufficient tools to manipulate this genome easily, quantitative trait loci (QTLs) that influence natural variation in behavior have been identified and tested for their effects on correlated behavioral traits. We review what is known about the genetics and physiology of two behavioral traits in honeybees, foraging specialization (pollen versus nectar), and defensive behavior, and present evidence that map-based cloning of genes is more feasible in the bee than in other metazoans. We also present bioinformatic analyses of candidate genes within QTL confidence intervals (CIs). The high recombination rate of the bee made it possible to narrow the search to regions containing only 17-61 predicted peptides for each QTL, although CIs covered large genetic distances. Knowledge of correlated behavioral traits, comparative bioinformatics, and expression assays facilitated evaluation of candidate genes. An overrepresentation of genes involved in ovarian development and insulin-like signaling components within pollen foraging QTL regions suggests that an ancestral reproductive gene network was co-opted during the evolution of foraging specialization. The major QTL influencing defensive/aggressive behavior contains orthologs of genes involved in central nervous system activity and neurogenesis. Candidates at the other two defensive-behavior QTLs include modulators of sensory signaling (Am5HT(7) serotonin receptor, AmArr4 arrestin, and GABA-B-R1 receptor). These studies are the first step in linking natural variation in honeybee social behavior to the identification of underlying genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.