ArticlePlanta2007
Arabidopsis ALS1 encodes a root tip and stele localized half type ABC transporter required for root growth in an aluminum toxic environment.
Article in Planta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed, 261 citations in OpenAlex.
- Elucidation of the genetic basis underlying rooting ability in vegetatively propagated chrysanthemum.Horticulture research · 2026Article
- GABA enhances broad bean aluminum tolerance via reducing uptake and reinforcing lignin and (iso)flavonoid synthesis.Plant cell reports · 2026Article
- Characterization of the Soybean (Plants (Basel, Switzerland) · 2025Article
- Comprehensive Analysis of theBiology · 2025Article
- Cadmium Stress Response of ABC Transporters inGenes · 2025Article
- CPK28-mediated CaNature communications · 2025Article
- CaNature communications · 2025Article
- A Genome-Wide Association Screen for Genes Affecting Leaf Trichome Development and Epidermal Metal Accumulation in Arabidopsis.Plant, cell & environment · 2025Article
- Review
- Article
- Genome-Wide Analyses of the SoybeanGenes · 2025Article
- Aluminum resistance in plants: A critical review focusing on STOP1.Plant communications · 2025Review
- Two genes encoding a bacterial-type ABC transporter function in aluminum tolerance in soybean.Plant cell reports · 2024Article
- SlSTOP1-regulatedHorticulture research · 2024Article
- Two Half-Size ATP-Binding Cassette Transporters Are Implicated in Aluminum Tolerance in Soybean.International journal of molecular sciences · 2024Article
- Systematic Investigation of Aluminum Stress-Related Genes and Their Critical Roles in Plants.International journal of molecular sciences · 2024Review
- The RAE1-STOP1-GL2-RHD6 module regulates the ALMT1-dependent aluminum resistance in Arabidopsis.Nature communications · 2024Article
- Article
- Physiological and Transcriptomic Analyses Reveal Commonalities and Specificities in Wheat in Response to Aluminum and Manganese.Current issues in molecular biology · 2024Article
- Investigating the involvement of potato (Frontiers in plant science · 2024Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aluminum toxicity in acid soils severely limits crop productivity through inhibition of root growth and, consequently, shoot development. Several Arabidopsis mutants were previously identified as having roots with Al hypersensitivity, suggesting that these represent deleterious mutations affecting genes required for either Al tolerance or resistance mechanisms. For this report, the als1-1 mutant was chosen for further characterization. The phenotype of als1-1 is most obviously presented in Al challenged roots, as evidenced by exaggerated root growth inhibition in conjunction with increased expression of Al-responsive genes compared to wt. Using a map-based cloning approach, the als1-1 mutation was isolated and found to represent a deleterious amino acid substitution in a previously uncharacterized half type ABC transporter, At5g39040, which is expressed in a non-Al dependent manner in all organs tested. GUS-dependent analyses revealed that ALS1 expression is primarily localized to the root tip and the vasculature throughout the plant. Concomitant with this, an ALS1: GFP fusion accumulates at the vacuolar membrane of root cells, indicating that ALS1 may be important for intracellular movement of some substrate, possibly chelated Al, as part of a mechanism of Al sequestration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.