SynthesisJournal of human genetics2007
Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis.
Synthesis in Journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Association of MTHFR C667T polymorphism with bone mineral density and fracture risk: an updated meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Pooled it
- ABO blood group system and gastric cancer: a case-control study and meta-analysis.International journal of molecular sciences · 2012Pooled it
- The TT genotype of methylenetetrahydrofolate reductase 677C>T polymorphism increases the susceptibility to pediatric ischemic stroke: meta-analysis of the 822 cases and 1,552 controls.Molecular biology reports · 2012Pooled it
- Pooled it
- Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.Journal of human genetics · 2008Pooled it
- Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026Article
- Targeting Homocysteine and Hydrogen Sulfide Balance as Future Therapeutics in Cancer Treatment.Antioxidants (Basel, Switzerland) · 2023Review
- Apolipoprotein E Gene Polymorphism Effects on Lipid Metabolism and Risk of Cerebral Infarction in Northwest Han Chinese Population.Pharmacogenomics and personalized medicine · 2023Article
- Transmembrane protease serine 2 (Life science alliance · 2022Article
- Article
- Methylenetetrahydrofolate reductase C677T gene polymorphism and the association with dyslipidemia in type 2 diabetic Palestinian patients.Journal of clinical laboratory analysis · 2021Article
- A prospective cohort study of MTHFR C677T gene polymorphism and its influence on the therapeutic effect of homocysteine in stroke patients with hyperhomocysteinemia.BMC neurology · 2020Article
- Methylenetetrahydrofolate reductase C677T variant and hyperhomocysteinemia in subarachnoid hemorrhage patients from India.Metabolic brain disease · 2018Article
- Association ofOncotarget · 2017Article
- The role of genetic risk factors in arterial ischemic stroke in pediatric and adult patients: a critical review.Molecular biology reports · 2014Review
- A magnetic nanoparticles-based method for DNA extraction from the saliva of stroke patients.Neural regeneration research · 2013Article
- Angiotensinogen gene polymorphism and ischemic stroke in East Asians: A meta-analysis.Neural regeneration research · 2013Article
- Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis.Experimental and therapeutic medicine · 2013Article
- Large-scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,797 individuals.Indian journal of human genetics · 2011Article
- Bio-Repository of DNA in stroke (BRAINS): a study protocol.BMC medical genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is a heterogeneous multifactorial disease and is thought to have a polygenic basis. Case-control studies on gene sequence variations have identified a number of potential genetic predisposition factors, but due to the conflicting results, uncertainty remains on the effect of these polymorphisms on risk for the development of stroke. To qualitatively and quantitatively assess the risk associated with different gene polymorphisms for stroke in Asian populations, we comprehensively searched and identified all the studies of association. Clinically overt case-control studies were selected only if neuroimaging had been used as the confirmatory measure for diagnosis of stroke. We performed a meta-analysis of the three most investigated genes, viz., methylenetetrahydrofolate reductase (MTHFR), apolipoprotein E (ApoE) and angiotensin-converting enzyme (ACE). Statistically significant association with stroke were identified for C677T polymorphism of MTHFR [random effects odds ratio (OR) = 1.47, 95% confidence interval (95% CI) 1.19, 1.82; P = 0.0004] and marginally significant association was detected with allele epsilon 4 of ApoE (random effects OR = 1.47, 95% CI 1.00, 2.15; P = 0.049). The sensitivity analysis (exclusion of studies with controls not in Hardy-Weinberg equilibrium) revealed a significant association of stroke with the MTHFR C677T and ApoE epsilon 4 alleles but showed no association with ACE gene insertion/deletion polymorphism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.