ArticleCanadian journal of gastroenterology = Journal canadien de gastroenterologie2006
13C urea breath test for (Helicobacter pylori): determination of the optimal cut-off point in a Canadian community population.
Article in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-invasive diagnostic tests for Helicobacter pylori infection.The Cochrane database of systematic reviews · 2018Pooled it
- Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial.Chinese journal of integrative medicine · 2017Trial
- ImprovingFrontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- Cut-off points for serum ferritin to identify low iron stores during the first year of life in a cohort of Mexican infants.Maternal & child nutrition · 2021Article
- A re-testing range is recommended forGut pathogens · 2021Article
- Optimization ofJournal of clinical laboratory analysis · 2019Article
- Investigation of HelicobacterPeerJ · 2017Article
- Diagnostic Methods of Helicobacter pylori Infection for Epidemiological Studies: Critical Importance of Indirect Test Validation.BioMed research international · 2016Review
- Validation of Urine Test for Detection of Helicobacter pylori Infection in Indonesian Population.BioMed research international · 2015Article
- Low prevalence of Helicobacter pylori infection in Canadian children: a cross-sectional analysis.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2008Article
- An optimized 13C-urea breath test for the diagnosis of H pylori infection.World journal of gastroenterology · 2007Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the test characteristics and the optimal cut-off point for the (13)C urea breath test ((13)C UBT) in a Canadian community laboratory setting.
methodsOf 2232 patients (mean age +/- SD: 51+/-21 years, 56% female) who completed a (13)C UBT, 1209 were tested to evaluate the primary diagnosis of (Helicobacter pylori) infection and 1023 were tested for confirmation of eradication following treatment. Cluster analysis was performed on the (13)C UBT data to determine the optimal cut-off point and the risk of false-positive and false-negative results. Additionally, 176 patients underwent endoscopic biopsy to allow validation of the sensitivity and specificity of the (13)C UBT against histology and microbiology using the calculated cut-off point.
resultsThe calculated cut-off points were 3.09 delta/1000 for the whole study population (n=2232), 3.09 delta/1000 for the diagnosis group (n=1209) and 2.88 delta/1000 for the post-treatment group (n=1023). When replacing the calculated cut-off points by a practical cut-off point of 3.0 delta/1000, the risk of false-positive and false-negative results was lower than 2.3%. The (13)C UBT showed 100% sensitivity and 98.5% specificity compared with histology and microbiology (n=176) for the diagnosis of active (H pylori) infection.
conclusionsThe (13)C UBT is an accurate, noninvasive test for the diagnosis of (H pylori) infection and for confirmation of cure after eradication therapy. The present study confirms the validity of a cut-off point of 3.0 delta/1000 for the (13)C UBT when used in a large Canadian community population according to a standard protocol.
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