ArticleLeukemia2007
T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34(+)CD38(-)CD7(+) common lymphoid progenitors expressing lymphoid-specific genes.
Article in Leukemia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 88 citations in OpenAlex.
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- Explainable graph learning for multimodal single-cell data integration.BMC bioinformatics · 2026Article
- Interleukin-6 restricts pre-thymic T cell lineage commitment of progenitors driving loss of SIV control.bioRxiv : the preprint server for biology · 2026Article
- A Thymus-Independent Artificial Organoid System Supports Complete Thymopoiesis from Rhesus Macaque-Derived Hematopoietic Stem and Progenitor Cells.Biomedicines · 2025Article
- Conserved interactions with stromal and immune cells coordinate de novo B cell lymphopoiesis in fetal intestines.JCI insight · 2025Article
- A thymus-independent artificial organoid system supports complete thymopoiesis from Rhesus macaque-derived hematopoietic stem and progenitor cells.bioRxiv : the preprint server for biology · 2025Article
- T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025Review
- Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation.iScience · 2023Article
- Single-cell multiomics of human fetal hematopoiesis define a developmental-specific population and a fetal signature.Blood advances · 2023Article
- Circulating IRF8-expressing CD123Trends in immunology · 2023Review
- Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF.Nature immunology · 2023Article
- Naturally selected CD7 CAR-T therapy without genetic editing demonstrates significant antitumour efficacy against relapsed and refractory acute myeloid leukaemia (R/R-AML).Journal of translational medicine · 2022Article
- Novel germline TRAF3IP3 mutation in a dyad with familial acute B lymphoblastic leukemia.Cancer reports (Hoboken, N.J.) · 2021Article
- Screening of Graves' disease susceptibility genes by whole exome sequencing in a three-generation family.BMC medical genomics · 2021Article
- Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level.Cell research · 2020Article
- CD34 expression does not correlate with immunophenotypic stem cell or progenitor content in human cord blood products.Blood advances · 2020Article
- Is Hematopoietic Stem Cell Transplantation Required to Unleash the Full Potential of Immunotherapy in Acute Myeloid Leukemia?Journal of clinical medicine · 2020Review
- Group 2 Innate Lymphoid Cells in Human Respiratory Disorders.Journal of innate immunity · 2020Review
- Review
- HIV Impacts CD34Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematopoietic stem cells in the bone marrow (BM) give rise to all blood cells. According to the classic model of hematopoiesis, the differentiation paths leading to the myeloid and lymphoid lineages segregate early. A candidate 'common lymphoid progenitor' (CLP) has been isolated from CD34(+)CD38(-) human cord blood cells based on CD7 expression. Here, we confirm the B- and NK-differentiation potential of CD34(+)CD38(-)CD7(+) cells and show in addition that this population has strong capacity to differentiate into T cells. As CD34(+)CD38(-)CD7(+) cells are virtually devoid of myeloid differentiation potential, these cells represent true CLPs. To unravel the molecular mechanisms underlying lymphoid commitment, we performed genome-wide gene expression profiling on sorted CD34(+)CD38(-)CD7(+) and CD34(+)CD38(-)CD7(-) cells. Interestingly, lymphoid-affiliated genes were mainly upregulated in the CD7(+) population, while myeloid-specific genes were downregulated. This supports the hypothesis that lineage commitment is accompanied by the shutdown of inappropriate gene expression and the upregulation of lineage-specific genes. In addition, we identified several highly expressed genes that have not been described in hematopoiesis before.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.