ArticleThe EMBO journal2007
Novel TRF1/BRF target genes revealed by genome-wide analysis of Drosophila Pol III transcription.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Genomic and structural insights into TATA-Binding protein from cestodes.Transcription · 2026Article
- Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity.PLoS biology · 2024Article
- snoRNPs: Functions in Ribosome Biogenesis.Biomolecules · 2020Review
- The RNA Polymerase II Core Promoter inGenetics · 2019Review
- The punctilious RNA polymerase II core promoter.Genes & development · 2017Review
- TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression.Scientific reports · 2016Article
- Transcriptional control of an essential ribozyme in Drosophila reveals an ancient evolutionary divide in animals.PLoS genetics · 2015Article
- Insulator function and topological domain border strength scale with architectural protein occupancy.Genome biology · 2014Article
- Differential utilization of TATA box-binding protein (TBP) and TBP-related factor 1 (TRF1) at different classes of RNA polymerase III promoters.The Journal of biological chemistry · 2013Article
- Expanding the genetic code of Drosophila melanogaster.Nature chemical biology · 2012Article
- TBP-related factors: a paradigm of diversity in transcription initiation.Cell & bioscience · 2011Article
- General transcription factors and subunits of RNA polymerase III: Paralogs for promoter- and cell type-specific transcription in multicellular eukaryotes.Transcription · 2010Article
- Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.Genome research · 2010Article
- Promoting developmental transcription.Development (Cambridge, England) · 2010Review
- Shifting players and paradigms in cell-specific transcription.Molecular cell · 2009Review
- Flynet: a genomic resource for Drosophila melanogaster transcriptional regulatory networks.Bioinformatics (Oxford, England) · 2009Article
- Molecular evolution of the testis TAFs of Drosophila.Molecular biology and evolution · 2009Article
- Specific variants of general transcription factors regulate germ cell development in diverse organisms.Biochimica et biophysica acta · 2009Review
- TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription.Genes & development · 2008Article
- In vivo analysis of Caenorhabditis elegans noncoding RNA promoter motifs.BMC molecular biology · 2008Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metazoans have evolved multiple paralogues of the TATA binding protein (TBP), adding another tunable level of gene control at core promoters. While TBP-related factor 1 (TRF1) shares extensive homology with TBP and can direct both Pol II and Pol III transcription in vitro, TRF1 target sites in vivo have remained elusive. Here, we report the genome-wide identification of TRF1-binding sites using high-resolution genome tiling microarrays. We found 354 TRF1-binding sites genome-wide with approximately 78% of these sites displaying colocalization with BRF. Strikingly, the majority of TRF1 target genes are Pol III-dependent small noncoding RNAs such as tRNAs and small nonmessenger RNAs. We provide direct evidence that the TRF1/BRF complex is functionally required for the activity of two novel TRF1 targets (7SL RNA and small nucleolar RNAs). Our studies suggest that unlike most other eukaryotic organisms that rely on TBP for Pol III transcription, in Drosophila and possibly other insects the alternative TRF1/BRF complex appears responsible for the initiation of all known classes of Pol III transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.