ArticleThe Korean journal of parasitology2006
Interactions between secreted GRA proteins and host cell proteins across the paratitophorous vacuolar membrane in the parasitism of Toxoplasma gondii.
Article in The Korean journal of parasitology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Dense granule proteins: key mediators ofFrontiers in medicine · 2026Review
- Toxoplasma-host endoplasmic reticulum interaction: HowCurrent research in microbial sciences · 2024Review
- Preparation and Preliminary Application of Epitope Peptide-Based Antibody againstTropical medicine and infectious disease · 2023Article
- Descriptive Comparison of ELISAs for the Detection ofPathogens (Basel, Switzerland) · 2021Review
- Disruption of Dense Granular Protein 2 (GRA2) Decreases the Virulence ofFrontiers in veterinary science · 2021Article
- Article
- Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system.Parasitology research · 2018Article
- Toxoplasma gondii GRA8 induces ATP5A1-SIRT3-mediated mitochondrial metabolic resuscitation: a potential therapy for sepsis.Experimental & molecular medicine · 2018Article
- Screening and identification of host proteins interacting with Toxoplasma gondii SAG2 by yeast two-hybrid assay.Parasites & vectors · 2017Article
- Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins.Microbiome · 2017Article
- Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα.PLoS pathogens · 2017Article
- Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity.Infection and immunity · 2016Article
- Comparative mapping of host-pathogen protein-protein interactions.Current opinion in microbiology · 2015Review
- Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.The Journal of experimental medicine · 2014Article
- Recombinant dense granular protein (GRA5) for detection of human toxoplasmosis by Western blot.BioMed research international · 2014Article
- Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.PloS one · 2012Article
- Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.Schizophrenia bulletin · 2009Review
- GRA proteins of Toxoplasma gondii: maintenance of host-parasite interactions across the parasitophorous vacuolar membrane.The Korean journal of parasitology · 2009Review
- Interaction between parasitophorous vacuolar membrane-associated GRA3 and calcium modulating ligand of host cell endoplasmic reticulum in the parasitism of Toxoplasma gondii.The Korean journal of parasitology · 2008Article
- Nucleolar translocalization of GRA10 of Toxoplasma gondii transfectionally expressed in HeLa cells.The Korean journal of parasitology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions between GRA proteins of dense granules in Toxoplasma gondii and host cell proteins were analyzed by yeast two-hybrid technique. The cMyc-GRA fusion proteins expressed from pGBKT7 plasmid in Y187 yeast were bound to host cell proteins from pGADT7-Rec-HeLa cDNA library transformed to AH109 yeast by mating method. By the selection procedures, a total of 939 colonies of the SD/-AHLT culture, 348 colonies of the X-alpha-gal positive and PCR, 157 colonies of the X-beta-gal assay were chosen for sequencing the cDNA and finally 90 colonies containing ORF were selected to analyze the interactions. GRA proteins interacted with a variety of host cell proteins such as enzymes, structural and functional proteins of organellar proteins of broad spectrum. Several specific bindings of each GRA protein to host proteins were discussed presumptively the role of GRA proteins after secreting into the parasitophorous vacuoles (PV) and the PV membrane in the parasitism of this parasite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.