ArticleThe Journal of general virology2007
OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions.
Article in The Journal of general virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response.Molecular biology reports · 2021Review
- Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- KRAB-ZFP Repressors Enforce Quiescence of Oncogenic Human Herpesviruses.Journal of virology · 2018Article
- Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family.Mobile DNA · 2015Review
- Article
- Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.The Journal of general virology · 2012Article
- Mining functional gene modules linked with rheumatoid arthritis using a SNP-SNP network.Genomics, proteomics & bioinformatics · 2012Article
- Molecular Understanding of HIV-1 Latency.Advances in virology · 2012Article
- Gypsy and the birth of the SCAN domain.Journal of virology · 2011Article
- Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro.Respiratory research · 2010Article
- Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.Retrovirology · 2010Review
- Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Article
- YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Article
- Adaptive evolution in zinc finger transcription factors.PLoS genetics · 2009Article
- Characterization of gene expression regulated by human OTK18 using Drosophila melanogaster as a model system for innate immunity.Journal of genetics · 2008Article
- Kruppel-associated box (KRAB) proteins in the adaptive immune system.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
It has previously been shown by our laboratory that OTK18, a human immunodeficiency virus (HIV)-inducible zinc-finger protein, reduces progeny-virion production in infected human macrophages. OTK18 antiviral activity is mediated through suppression of Tat-induced HIV-1 long terminal repeat (LTR) promoter activity. Through the use of LTR-scanning mutant vectors, the specific regions responsible for OTK18-mediated LTR suppression have been defined. Two different LTR regions were identified as potential OTK18-binding sites by an enhanced DNA-transcription factor ELISA system; the negative-regulatory element (NRE) at -255/-238 and the Ets-binding site (EBS) at -150/-139 in the LTR. In addition, deletion of the EBS in the LTR blocked OTK18-mediated LTR suppression. These data indicate that OTK18 suppresses LTR activity through two distinct regulatory elements. Spontaneous mutations in these regions might enable HIV-1 to escape from OTK18 antiretroviral activity in human macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.