ArticleThe Journal of physiology2007
Axonal and somatic filtering of antidromically evoked cortical excitation by simulated deep brain stimulation in rat brain.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Presurgical structural imaging and clinical outcome in combined bed nucleus of the stria terminalis-nucleus accumbens deep brain stimulation for treatment-resistant depression.General psychiatry · 2024Article
- Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex.Nature communications · 2023Article
- The Therapeutic Frequency Profile of Subthalamic Nucleus Deep Brain Stimulation in Rats Is Shaped by Antidromic Spike Failure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The cortical evoked potential corresponds with deep brain stimulation efficacy in rats.Journal of neurophysiology · 2022Article
- Frequency-dependent spike-pattern changes in motor cortex during thalamic deep brain stimulation.Journal of neurophysiology · 2020Article
- Resting-state functional connectivity modulates the BOLD activation induced by nucleus accumbens stimulation in the swine brain.Brain and behavior · 2019Article
- Deep brain stimulation induces sparse distributions of locally modulated neuronal activity.Scientific reports · 2018Article
- Simulation Study of Intermittent Axonal Block and Desynchronization Effect Induced by High-Frequency Stimulation of Electrical Pulses.Frontiers in neuroscience · 2018Article
- Novel Stimulation Paradigms with Temporally-Varying Parameters to Reduce Synchronous Activity at the Onset of High Frequency Stimulation in Rat Hippocampus.Frontiers in neuroscience · 2017Article
- Deep Brain Stimulation Frequency-A Divining Rod for New and Novel Concepts of Nervous System Function and Therapy.Brain sciences · 2016Review
- Model-Based Comparison of Deep Brain Stimulation Array Functionality with Varying Number of Radial Electrodes and Machine Learning Feature Sets.Frontiers in computational neuroscience · 2016Article
- Fidelity of frequency and phase entrainment of circuit-level spike activity during DBS.Journal of neurophysiology · 2015Article
- Therapeutic mechanisms of high-frequency stimulation in Parkinson's disease and neural restoration via loop-based reinforcement.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Early hypersynchrony in juvenile PINK1(-)/(-) motor cortex is rescued by antidromic stimulation.Frontiers in systems neuroscience · 2014Article
- Effects of antidromic and orthodromic activation of STN afferent axons during DBS in Parkinson's disease: a simulation study.Frontiers in computational neuroscience · 2014Article
- Closing the loop of deep brain stimulation.Frontiers in systems neuroscience · 2013Review
- Functional disconnection of axonal fibers generated by high frequency stimulation in the hippocampal CA1 region in-vivo.Brain research · 2013Article
- A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.PloS one · 2013Article
- Electrophysiological study of supraspinal input and spinal output of cat's subnucleus reticularis dorsalis (SRD) neurons.PloS one · 2013Article
- Short latency activation of cortex during clinically effective subthalamic deep brain stimulation for Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antidromic cortical excitation has been implicated as a contributing mechanism for high-frequency deep brain stimulation (DBS). Here, we examined the reliability of antidromic responses of type 2 corticofugal fibres in rat over a stimulation frequency range compatible to the DBS used in humans. We activated antidromically individual layer V neurones by stimulating their two subcortical axonal branches. We found that antidromic cortical excitation is not as reliable as generally assumed. Whereas the fast conducting branches of a type 2 axon in the highly myelinated brainstem region follow high-frequency stimulation, the slower conducting fibres in the poorly myelinated thalamic region function as low-pass filters. These fibres fail to transmit consecutive antidromic spikes at the beginning of high-frequency stimulation, but are able to maintain a steady low-frequency (6-12 Hz) spike output during the stimulation. In addition, antidromic responses evoked from both branches are rarely present in cortical neurones with a more hyperpolarized membrane potential. Our data indicate that axon-mediated antidromic excitation in the cortex is strongly influenced by the myelo-architecture of the stimulation site and the excitability of individual cortical neurones.
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