ArticleThe Journal of physiology2007
Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
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- Firing properties of single axons with cardiac rhythmicity in the human cervical vagus nerve.The Journal of physiology · 2025Article
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Peritoneal sepsis caused by Escherichia coli triggers brainstem inflammation and alters the function of sympatho-respiratory control circuits.Journal of neuroinflammation · 2024Article
- Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles.Bioelectronic medicine · 2023Article
- Fiber optical imaging of astroglial calcium signaling in the respiratory network in the working heart brainstem preparation.Frontiers in physiology · 2023Article
- Advancing respiratory-cardiovascular physiology with the working heart-brainstem preparation over 25 years.The Journal of physiology · 2022Review
- Cellular basis of learning and memory in the carotid body.Frontiers in synaptic neuroscience · 2022Review
- Heartbeats entrain breathing via baroreceptor-mediated modulation of expiratory activity.Experimental physiology · 2021Article
- Functional-Optical Coherence Tomography: A Non-invasive Approach to Assess the Sympathetic Nervous System and Intrinsic Vascular Regulation.Frontiers in physiology · 2019Article
- Cardiovascular autonomic regulation, inflammation and pain in rheumatoid arthritis.Autonomic neuroscience : basic & clinical · 2017Observational
- Physiologic regulation of heart rate and blood pressure involves connexin 36-containing gap junctions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Increased sympathetic nerve activity and reduced cardiac baroreflex sensitivity in rheumatoid arthritis.The Journal of physiology · 2017Article
- Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia.The Journal of physiology · 2016Article
- Acute Response to Unilateral Unipolar Electrical Carotid Sinus Stimulation in Patients With Resistant Arterial Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Sympathetic overactivity occurs before hypertension in the two-kidney, one-clip model.Experimental physiology · 2016Article
- Deep brain stimulation for the treatment of resistant hypertension.Current hypertension reports · 2014Review
- An afferent explanation for sexual dimorphism in the aortic baroreflex of rat.American journal of physiology. Heart and circulatory physiology · 2014Article
- Central regulation of heart rate and the appearance of respiratory sinus arrhythmia: new insights from mathematical modeling.Mathematical biosciences · 2014Article
- Revealing the role of the autonomic nervous system in the development and maintenance of Goldblatt hypertension in rats.Autonomic neuroscience : basic & clinical · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The arterial baroreflex acts to buffer acute changes in blood pressure by reciprocal modulation of sympathetic and parasympathetic activity that controls the heart and vasculature. We have examined the baroreflex pressure-function curves for changes in heart rate and non-cardiac sympathetic nerve activity (SNA, thoracic chain T8-12) in artificially perfused in situ rat preparations. We found that the non-cardiac SNA baroreflex is active over a lower range of pressures than the cardiac baroreflex (threshold 66 +/- 1 mmHg versus 82 +/- 5 mmHg and mid-point 77 +/- 3 versus 87 +/- 4 mmHg, respectively, P < 0.05, n = 6). This can manifest as a complete dissociation of the baroreflex limbs at low pressures. This difference between the cardiac and non-cardiac SNA baroreflex is also seen in end-organ sympathetic outflows (adrenal and renal nerves). Recordings of the cardiac vagal (parasympathetic) and the inferior cardiac (sympathetic) nerves identify the cardiac parasympathetic baroreflex component as being active over a higher range of pressures. This difference in the operating range of the baroreflex-function curves is exaggerated in the spontaneously hypertensive rat where the cardiac component has selectively reset by 20-25 mmHg to a higher pressure range (threshold of 104 +/- 4 mmHg and mid-point 113 +/- 4, n = 6). The difference in the pressure-function curves for the cardiac versus the vascular baroreflex indicates that there is a hierarchical recruitment of the output limbs of the baroreflex with a sympathetic predominance at lower arterial pressures.
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