ArticleNucleic acids research2007
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Interactions of two large antiviral polyamides with the long control region of HPV16.Biochimie · 2016Article
- Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells.Bioorganic & medicinal chemistry letters · 2012Article
- Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.Nucleic acids research · 2012Article
- Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit.Journal of the American Chemical Society · 2008Article
- Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.Molecular cancer therapeutics · 2008Article
- Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate.PloS one · 2008Article
- Alpha-diaminobutyric acid-linked hairpin polyamides.Bioorganic & medicinal chemistry · 2007Article
- Completion of a Programmable DNA-Binding Small Molecule Library.Tetrahedron · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Hairpin polyamide-chlorambucil conjugates containing an alpha-diaminobutyric acid (alpha-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized gamma-DABA turn. Although the DNA-binding properties of unconjugated polyamides are similar, the alpha-DABA conjugates display increased alkylation specificity and decreased rate of reaction. Treatment of a human colon carcinoma cell line with alpha-DABA versus gamma-DABA hairpin conjugates shows only slight differences in toxicities while producing similar effects on cell morphology and G2/M stage cell cycle arrest. However, striking differences in animal toxicity between the two classes are observed. Although mice treated with an alpha-DABA hairpin polyamide do not differ significantly from control mice, the analogous gamma-DABA hairpin is lethal. This dramatic difference from a subtle structural change would not have been predicted.
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Registered trials
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