ArticleThe Biochemical journal1991
Antibody mapping of tissue factor implicates two different exon-encoded regions in function.
Article in The Biochemical journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Engineering of a membrane-triggered activity switch in coagulation factor VIIa.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Glycosylation of tissue factor is not essential for its transport or functions.Journal of thrombosis and haemostasis : JTH · 2011Article
- Tissue factor-bearing microparticles and thrombus formation.Arteriosclerosis, thrombosis, and vascular biology · 2011Review
- Disulfide isomerization switches tissue factor from coagulation to cell signaling.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Cross-talk of integrin alpha3beta1 and tissue factor in cell migration.Molecular biology of the cell · 2004Article
- Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Expression of tissue factor in non-small-cell lung cancers and its relationship to metastasis.British journal of cancer · 1999Article
- A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280.The Journal of cell biology · 1998Article
- Ligand-induced protease receptor translocation into caveolae: a mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway.The Journal of cell biology · 1996Article
- In situ characterization of antigenic and functional tissue factor expression in human tumors utilizing monoclonal antibodies and recombinant factor VIIa as probes.The American journal of pathology · 1994Article
- Structural requirements for the interaction between tissue factor and factor VII: characterization of chymotrypsin-derived tissue factor polypeptides.The Biochemical journal · 1993Article
- The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms.Journal of virology · 1993Article
- Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site.The Biochemical journal · 1992Article
- Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tissue Factor (TF), a small transmembrane glycoprotein, is the cellular receptor for the zymogen Factor VII and the serine protease Factor VIIa (VIIa). TF provides cofactor function for VIIa in the catalytically active (TF: VIIa) binary complex. To explore the structural loci of TF that are responsible for binding of VII and VIIa, monoclonal antibodies (MAbs) and sequence-specific polyclonal antibodies to the native TF protein were analysed for inhibition of VII binding. Two independent epitopes of MAbs were localized by reciprocal competition and by binding of the MAbs to different proteolytic fragments of TF. The epitopes were also characterized in part by progressive C-terminal deletional mutation of the TF protein. Reactivity of the anti-(locus II) MAb TF9-6G4 is consistent with epitope localization in residues Thr40-Val83, encoded by exon 3. In contrast, the anti-(locus I) MAb TF9-5G9 was reactive with fragments encompassing exon 4 (Thr106-Lys165). Antibodies to linear sequences encoded by the same two exons also inhibited VII binding. These data suggest a minimum requirement for two of the four exon-encoded regions of TF for the functional integrity of this receptor cofactor with respect to ligand recognition and high-affinity binding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.