ArticleProceedings of the National Academy of Sciences of the United States of America1991
Transcription factor AP2 and its role in epidermal-specific gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 238 citations in OpenAlex.
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- CNEReg Interprets Ruminant-specific Conserved Non-coding Elements by Developmental Gene Regulatory Network.Genomics, proteomics & bioinformatics · 2023Article
- Advances in Rice Seed Shattering.International journal of molecular sciences · 2023Review
- DNA Repair Genes Polymorphisms: Impact on Acute Myeloid Leukemia Patients Outcome.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis.eLife · 2021Article
- Mutant Single Nucleotide Polymorphism rs189037 in Ataxia-Telangiectasia Mutated Gene Is Significantly Associated With Ventricular Wall Thickness and Human Lifespan.Frontiers in cardiovascular medicine · 2021Article
- Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near humaneLife · 2020Article
- Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancer.Oncogenesis · 2019Article
- The gene regulatory basis of genetic compensation during neural crest induction.PLoS genetics · 2019Article
- IRF6 and AP2A Interaction Regulates Epidermal Development.The Journal of investigative dermatology · 2018Article
- The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture.The Journal of biological chemistry · 2018Article
- Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study.PloS one · 2014Article
- AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning.Cell research · 2012Article
- Interferon regulatory factor 6 is necessary, but not sufficient, for keratinocyte differentiation.The Journal of investigative dermatology · 2012Article
- Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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- Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.Developmental biology · 2008Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epidermis is a stratified squamous epithelium whose major differentiation-specific products are keratins. To elucidate factors controlling keratinocyte-specific gene expression, we previously identified proximal and distal regulatory elements that act synergistically to drive keratinocyte-specific expression of the gene encoding human epidermal keratin K14. Control by the proximal element is mediated by a transcription factor, KER1, which is more abundant in nuclear extracts of keratinocytes than in extracts of other cell types, including fibroblasts, lymphocytes, and simple epithelial cells. In this report, we identify this factor as transcription factor AP2, shown to be transcribed in cells of epidermal and neural crest lineages. Furthermore, we demonstrate functional AP2 binding sites upstream from three additional epidermal genes, suggesting that AP2 may be generally involved in epidermal gene regulation. Finally, although AP2 is necessary, it is not sufficient for epidermal gene expression: a distal element contributes to tissue-specific expression of the human keratin K14 gene as judged by its ability to enhance expression of a heterologous promoter in keratinocytes but not in hepatoma cells. These results imply that a combination of factors is likely to contribute to epidermal-specific expression of the human keratin K14 gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.