Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2006
Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study.
Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 8 registered trials, which are not on this map. Cited by 352 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical Exercise to Prevent Disability Pilot Study
Early Screening and Exercise for Prevention of Disability in Persons Residing in Continuing Care Retirement Communities
The LIFE Study - Lifestyle Interventions and Independence for Elders
Muscle Insulin Resistance In Aging
Functionally Designed Resistance Exercise With the Aim of Improving Balance, Muscle Strength, Muscle Mass and Physical Function of the Elderly: a Randomized Controlled Study
IMOVE: Improvisational Movement for People With Memory Loss and Their Caregivers
Frailty Rehabilitation: A Community-based Intervention to Promote Healthy Aging
Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors
Who cites it
352 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Community-based interventions to support aging in place and functional independence in older adults: a systematic review of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Diversity in United States Dementia Prevention Trials: An Updated Systematic Review of Eligibility Criteria and Recruitment Strategies.Dementia and geriatric cognitive disorders · 2025Pooled it
- Safety and Effectiveness of Long-Term Exercise Interventions in Older Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Effective Interventions on Improving Elderly's Independence in Activity of Daily Living: A Systematic Review and Logic Model.Frontiers in public health · 2020Pooled it
- Association of Long-term Exercise Training With Risk of Falls, Fractures, Hospitalizations, and Mortality in Older Adults: A Systematic Review and Meta-analysis.JAMA internal medicine · 2019Pooled it
- Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis.BMC medicine · 2016Pooled it
- Does an Innovative PT Program Targeting Mobility Benefit Veterans With Executive Function Deficit?Journal of the American Geriatrics Society · 2026Trial
- Intervention Mapping: A Framework to Co-Design the ALAPAGE Programme to Simultaneously Improve Dietary Diversity and Physical Fitness Among Older People.Health expectations : an international journal of public participation in health care and health policy · 2026Trial
- The "Reducing Inflammation for Greater Health Trial (RIGHT)" Study-Concept, Rationale, and Design.Journal of the American Geriatrics Society · 2026Trial
- Randomised feasibility trial of a remotely delivered holistic UK employee programme combining tailored sleep hygiene, diet, and physical activity counselling for weight management: a mixed-methods evaluation.Journal of nutritional science · 2026Trial
- Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations.Journal of cachexia, sarcopenia and muscle · 2025Trial
- BIO101 in Sarcopenic Seniors at Risk of Mobility Disability: Results of a Double-Blind Randomised Interventional Phase 2b Trial.Journal of cachexia, sarcopenia and muscle · 2025Trial
- Effect of resistance training on physical function during chemotherapy in colon cancer.JNCI cancer spectrum · 2024Trial
- Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- The Effectiveness of Frailty Intervention for Older Patients with Frailty during Hospitalization.The journal of nutrition, health & aging · 2023Trial
- The Effect of Low-Dose Aspirin on Frailty Phenotype and Frailty Index in Community-Dwelling Older Adults in the ASPirin in Reducing Events in the Elderly Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Health effects and cost-effectiveness of a multilevel physical activity intervention in low-income older adults; results from the PEP4PA cluster randomized controlled trial.The international journal of behavioral nutrition and physical activity · 2022Trial
- Trial
- Frailty and Depression in Late Life: A High-Risk Comorbidity With Distinctive Clinical Presentation and Poor Antidepressant Response.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Effect of Timing and Coordination Training on Mobility and Physical Activity Among Community-Dwelling Older Adults: A Randomized Clinical Trial.JAMA network open · 2022Trial
292 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
16 authors.
Funding
Abstract
backgroundThe Short Physical Performance Battery (SPPB), which includes walking, balance, and chair stands tests, independently predicts mobility disability and activities of daily living disability. To date, however, there is no definitive evidence from randomized controlled trials that SPPB scores can be improved. Our objective was to assess the effect of a comprehensive physical activity (PA) intervention on the SPPB and other physical performance measures.
methodsA total of 424 sedentary persons at risk for disability (ages 70-89 years) were randomized to a moderate-intensity PA intervention or a successful aging (SA) health education intervention and were followed for an average of 1.2 years.
resultsThe mean baseline SPPB score on a scale of 0-12, with 12 corresponding to highest performance, was 7.5. At 6 and 12 months, the PA versus SA group adjusted SPPB (+/- standard error) scores were 8.7 +/- 0.1 versus 8.0 +/- 0.1, and 8.5 +/- 0.1 versus 7.9 +/- 0.2, respectively (p < .001). The 400-meter walking speed was also significantly improved in the PA group. The PA group had a lower incidence of major mobility disability defined as incapacity to complete a 400-meter walk (hazard ratio = 0.71, 95% confidence interval = 0.44-1.20).
conclusionsA structured PA intervention improved the SPPB score and other measures of physical performance. An intervention that improves the SPPB performance may also offer benefit on more distal health outcomes, such as mobility disability.
Indexed as
Identifiers
17167156What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.