ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 86 citations in OpenAlex.
- Regulation of neural stem cells by innervating neurons.Journal of neurochemistry · 2025Review
- How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders.Frontiers in molecular neuroscience · 2022Review
- Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons.Frontiers in molecular neuroscience · 2022Article
- Precursor types predict the stability of neuronal branches.Journal of cell science · 2021Article
- Diversity and function of corticopetal and corticofugal GABAergic projection neurons.Nature reviews. Neuroscience · 2020Review
- Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology.Molecules (Basel, Switzerland) · 2019Review
- Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis.Annual review of neuroscience · 2018Review
- mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons.Developmental neurobiology · 2016Article
- Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis.Cold Spring Harbor perspectives in biology · 2016Review
- The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell.Neuroscience · 2016Review
- Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.Neuropharmacology · 2015Article
- Olfactory and cortical projections to bulbar and hippocampal adult-born neurons.Frontiers in neuroanatomy · 2015Article
- GABAergic control of depression-related brain states.Advances in pharmacology (San Diego, Calif.) · 2015Article
- Regulation of adult neurogenesis by GABAergic transmission: signaling beyond GABAA-receptors.Frontiers in cellular neuroscience · 2014Review
- GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity.Frontiers in cellular neuroscience · 2014Article
- Is integration and survival of newborn neurons the bottleneck for effective neural repair by endogenous neural precursor cells?Frontiers in neuroscience · 2014Article
- Role of NMDA receptors in adult neurogenesis: an ontogenetic (re)view on activity-dependent development.Cellular and molecular life sciences : CMLS · 2013Review
- Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Features of adult neurogenesis and neurochemical signaling in the Cherry salmon Oncorhynchus masou brain.Neural regeneration research · 2013Article
- Emerging neurotrophic role of GABAB receptors in neuronal circuit development.Frontiers in cellular neuroscience · 2013Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initial formation and growth of dendrites is a critical step leading to the integration of newly generated neurons into postnatal functional networks. However, the cellular mechanisms and extracellular signals regulating this process remain mostly unknown. By directly observing newborn neurons derived from the subventricular zone in culture as well as in olfactory bulb slices, we show that ambient GABA acting through GABA(A) receptors is essential for the temporal stability of lamellipodial protrusions in dendritic growth cones but did not interfere with filopodia dynamics. Furthermore, we provide direct evidence that ambient GABA is required for the proper initiation and elongation of dendrites by promoting the rapid stabilization of new dendritic segments after their extension. The effects of GABA on the initial formation of dendrites depend on depolarization and Ca2+ influx and are associated with a higher stability of microtubules. Together, our results indicate that ambient GABA is a key regulator of dendritic initiation in postnatally generated olfactory interneurons and offer a mechanism by which this neurotransmitter drives early dendritic growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.