ArticleProceedings of the National Academy of Sciences of the United States of America2006
Identification of a biomarker for sleep drive in flies and humans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 110 citations in OpenAlex.
- Trial
- Chronic psychosocial stressors and salivary biomarkers in emerging adults.Psychoneuroendocrinology · 2012Trial
- Treatment of obesity with extension of sleep duration: a randomized, prospective, controlled trial.Clinical trials (London, England) · 2010Trial
- Leveraging the Metabolic Fingerprint of Sleep Deprivation and Sleep Restriction for Forensic Applications: A Machine Learning Study in Oral Fluid Metabolomics.Journal of proteome research · 2026Article
- Accurate detection of acute sleep deprivation using a metabolomic biomarker-A machine learning approach.Science advances · 2024Article
- Association between sleep duration and dental caries in a nationally representative U.S. population.BMC oral health · 2023Article
- Biomarkers linking habitual short sleep duration with risk of cardiometabolic disease: current progress and future directions.Frontiers in sleep · 2023Article
- Depriving Mice of Sleep also Deprives of Food.Clocks & sleep · 2022Article
- Interest of the BLAST paradigm and salivary markers for the evaluation of sleepiness in drivers.Frontiers in neuroscience · 2022Article
- Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation.Clocks & sleep · 2020Article
- Developing preliminary blood metabolomics-based biomarkers of insufficient sleep in humans.Sleep · 2020Article
- Article
- AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance.PLoS genetics · 2018Article
- A Systematic Review on Non-mammalian Models in Epilepsy Research.Frontiers in pharmacology · 2018Article
- Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors.International journal of medical sciences · 2018Review
- Selection of Suitable Reference Genes for Analysis of Salivary Transcriptome in Non-Syndromic Autistic Male Children.International journal of molecular sciences · 2016Article
- Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: a pilot study.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- Article
- The Neonatal Salivary Transcriptome.Cold Spring Harbor perspectives in medicine · 2015Review
- Commentary: A Quest for a Novel Peripheral Biomarker for Narcolepsy.CNS neuroscience & therapeutics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
It is a common experience to sacrifice sleep to meet the demands of our 24-h society. Current estimates reveal that as a society, we sleep on average 2 h less than we did 40 years ago. This level of sleep restriction results in negative health outcomes and is sufficient to produce cognitive deficits and reduced attention and is associated with increased risk for traffic and occupational accidents. Unfortunately, there is no simple quantifiable marker that can detect an individual who is excessively sleepy before adverse outcomes become evident. To address this issue, we have developed a simple and effective strategy for identifying biomarkers of sleepiness by using genetic and pharmacological tools that dissociate sleep drive from wake time in the model organism Drosophila melanogaster. These studies have identified a biomarker, Amylase, that is highly correlated with sleep drive. More importantly, both salivary Amylase activity and mRNA levels are also responsive to extended waking in humans. These data indicate that the fly is relevant for human sleep research and represents a first step in developing an effective method for detecting sleepiness in vulnerable populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.