Evidence map›Paper›PMID 17166957›Full record

ArticleJournal of clinical microbiology2007

Use of hydrogen peroxide vapor for deactivation of Mycobacterium tuberculosis in a biological safety cabinet and a room.

Leslie Hall, Jonathan A Otter, John Chewins, Nancy L Wengenack

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 96 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. The Hitchhiker's Guide to Hydrogen Peroxide Fumigation, Part 1: Introduction to Hydrogen Peroxide Fumigation.Applied biosafety : journal of the American Biological Safety Association · 2020
    Review
  6. Determining the Effectiveness of Decontamination with Ionized Hydrogen Peroxide.Applied biosafety : journal of the American Biological Safety Association · 2020
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Opinion: Airtightness for Decontamination by Fumigation of High-Containment Laboratories.Applied biosafety : journal of the American Biological Safety Association · 2019
    Article
  13. Plasma-Activated Aerosolized Hydrogen Peroxide (aHP) in Surface Inactivation Procedures.Applied biosafety : journal of the American Biological Safety Association · 2019
    Article
  14. Improvement of Vivarium Biodecontamination through Data-acquisition Systems and Automation.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Mycobacteria inactivation using Engineered Water Nanostructures (EWNS).Nanomedicine : nanotechnology, biology, and medicine · 2014
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Leslie HallMayo Clinic, Rochester, MN 55905, USA.
Jonathan A Otter
John Chewins
Nancy L Wengenack
Bioquell (United Kingdom) · GBMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycobacterium tuberculosis is an important human pathogen that is routinely cultured in clinical and research laboratories. M. tuberculosis can contaminate surfaces and is highly resistant to disinfection. We investigated whether hydrogen peroxide vapor (HPV) is effective for the deactivation of M. tuberculosis on experimentally contaminated surfaces in a biological safety cabinet (BSC) and a room. Biological indicators (BIs) consisting of an approximately 3-log(10) inoculum of M. tuberculosis on stainless steel discs and a 6-log(10) inoculum of Geobacillus stearothermophilus were exposed to HPV in BSC time course experiments and at 10 locations during room experiments. In three separate BSC experiments, M. tuberculosis BIs were transferred to growth media at 15-min intervals during a 180-min HPV exposure period. No M. tuberculosis BIs grew following 30 min of HPV exposure. In three separate room experiments, M. tuberculosis and G. stearothermophilus BIs were exposed to HPV for 90, 120, and 150 min, respectively. BIs for both microorganisms were deactivated in all 10 locations following 90 min of HPV exposure. HPV provides an alternative to traditional decontamination methods, such as formaldehyde fumigation, for laboratories and other areas contaminated with M. tuberculosis.

Indexed as

Anti-Bacterial AgentsAtmosphere Exposure ChambersColony Count, MicrobialContainment of BiohazardsDecontaminationDisinfectionFumigationHumansHydrogen PeroxideLaboratory InfectionMycobacterium tuberculosisTuberculosisAnti-Bacterial AgentsHydrogen Peroxide

Identifiers

PMID17166957
PMCPMC1829131
OpenAlexW2164645611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.