ArticleJournal of virology2007
Evolutionary history and global spread of the emerging g12 human rotaviruses.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it, 315 citations in OpenAlex.
- Prevalence and Genetic Diversity of Rotaviruses among under-Five Children in Ethiopia: A Systematic Review and Meta-Analysis.Viruses · 2020Pooled it
- Factors contributing to the frequent interspecies transmission of G4P[6]Microbial genomics · 2026Article
- Feline Rotavirus A as a Source of Spillover Infections to Humans: An In-Depth Analysis of Molecular Epidemiological Evidence.Viruses · 2026Review
- Unveiling the Genomic Landscape of G2P[6] Rotavirus a Strains in Brazil: Evolutionary and Epidemiological Perspectives.Viruses · 2025Article
- Rotavirus prevalence and genotypes in the Central African Republic, 2011-2021.BMC infectious diseases · 2025Article
- Epidemiology and clinical features of Rotavirus infection among children in Rawalpindi, Pakistan.PloS one · 2025Article
- Genetic diversity and evolution of G12P[6] DS-1-like and G12P[9] AU-1-like Rotavirus strains in Brazil.Functional & integrative genomics · 2024Article
- Emergence of Intergenogroup Reassortant G9P[4] Strains Following Rotavirus Vaccine Introduction in Ghana.Viruses · 2023Article
- Whole-genome characterization of common rotavirus strains circulating in Vellore, India from 2002 to 2017: emergence of non-classical genomic constellations.Gut pathogens · 2023Article
- G6P[8] Rotavirus a Possessing a Wa-like VP3 Gene from a Child with Acute Gastroenteritis Living in the Northwest Amazon Region.Pathogens (Basel, Switzerland) · 2023Article
- Rotavirus infections and their genotype distribution in Rwanda before and after the introduction of rotavirus vaccination.PloS one · 2023Article
- Diversity of rotavirus strains circulating in Haiti before and after introduction of monovalent vaccine.IJID regions · 2022Article
- Enteropathogen Changes After Rotavirus Vaccine Scale-up.Pediatrics · 2022Article
- Post Vaccination Epidemiology and Genotyping of Rotavirus Gastroenteritis at a Tertiary Care Centre of North-East Rajasthan.Indian journal of pediatrics · 2021Observational
- The origins of G12P[6] rotavirus strains detected in Lebanon.The Journal of general virology · 2021Article
- Rotavirus Gastroenteritis in Western Uttar Pradesh, India.Indian journal of pediatrics · 2021Article
- Demographic Profile and Genotypic Distribution of Rotavirus Gastroenteritis from Rural Haryana, India.Indian journal of pediatrics · 2021Article
- Genetic characterization of G12P[6] and G12P[8] rotavirus strains collected in six African countries between 2010 and 2014.BMC infectious diseases · 2021Article
- Article
- Reverse Genetics Approach for Developing Rotavirus Vaccine Candidates Carrying VP4 and VP7 Genes Cloned from Clinical Isolates of Human Rotavirus.Journal of virology · 2020Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G12 rotaviruses were first detected in diarrheic children in the Philippines in 1987, but no further cases were reported until 1998. However, G12 rotaviruses have been detected all over the world in recent years. Here, we report the worldwide variations of G12 rotaviruses to investigate the evolutionary mechanisms by which they managed to spread globally in a short period of time. We sequenced the complete genomes (11 segments) of nine G12 rotaviruses isolated in Bangladesh, Belgium, Thailand, and the Philippines and compared them with the genomes of other rotavirus strains. Our genetic analyses revealed that after introduction of the VP7 gene of the rare G12 genotype into more common local strains through reassortment, a vast genetic diversity was generated and several new variants with distinct gene constellations emerged. These reassortment events most likely took place in Southeast Asian countries and spread to other parts of the world. The acquirement of gene segments from human-adapted rotaviruses might allow G12 to better propagate in humans and hence to develop into an important emerging human pathogen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.