ArticleThe British journal of ophthalmology2007
Human papillomavirus in normal conjunctival tissue and in conjunctival papilloma: types and frequencies in a large series.
Article in The British journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 91 citations in OpenAlex.
- LRIG1 as a potential novel marker for neoplastic transformation in ocular surface squamous neoplasia.PloS one · 2014Trial
- Pediatric conjunctival papilloma managed with staged multimodal therapy: a case report.BMC ophthalmology · 2026Article
- Ocular Findings in Women with Cervical HPV Positivity and Cervical Dysplasia Undergoing Loop Electrosurgical Excision Procedure: A Prospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Can high-resolution optical coherence tomography provide an optical biopsy for ocular surface lesions?Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2025Review
- Infectious etiologies of conjunctival tumors.Expert review of ophthalmology · 2025Article
- Conjunctival papilloma treatment outcomes: a 12-year-retrospective study.Eye (London, England) · 2023Article
- Conjunctival papilloma: a case report and a brief review of literature.Annals of translational medicine · 2023Article
- [Diagnosis and treatment of benign eyelid tumors].Die Ophthalmologie · 2023Review
- Detection of Human Papillomavirus in Squamous Lesions of the Conjunctiva Using RNA and DNA In-Situ Hybridization.International journal of molecular sciences · 2022Article
- Viral and Genomic Drivers of Squamous Cell Neoplasms Arising in the Lacrimal Drainage System.Cancers · 2022Article
- Review
- MACE RNA sequencing analysis of conjunctival squamous cell carcinoma and papilloma using formalin-fixed paraffin-embedded tumor tissue.Scientific reports · 2020Article
- Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis.Human genetics · 2020Review
- Article
- Paediatric virology and human papillomaviruses: An update.Experimental and therapeutic medicine · 2019Article
- Human papillomavirus infection and ocular surface disease (Review).International journal of oncology · 2019Review
- Update on Diagnosis and Management of Conjunctival Papilloma.Eye and vision (London, England) · 2019Review
- Inverted papilloma of the conjunctiva.BMJ open ophthalmology · 2019Article
- Herpes Simplex Virus and Human Papillomavirus Coinfections in Hyperimmunoglobulin E Syndrome Presenting as a Conjunctival Mass Lesion.Case reports in medicine · 2017Article
- Interferon alfa-2b in the management of recurrent conjunctival papillomatosis.Indian journal of ophthalmology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine conjunctival papilloma and normal conjunctival tissue for the presence of human papillomavirus (HPV).
methodsArchival paraffin wax-embedded tissue from 165 conjunctival papillomas and from 20 histological normal conjunctival biopsy specimens was analysed for the presence of HPV by PCR. Specimens considered HPV positive using consensus primers, but with a negative or uncertain PCR result using type-specific HPV probes, were analysed with DNA sequencing.
resultsHPV was present in 86 of 106 (81%) beta-globin-positive papillomas. HPV type 6 was positive in 80 cases, HPV type 11 was identified in 5 cases and HPV type 45 was present in a single papilloma. All the 20 normal conjunctival biopsy specimens were beta-globin positive and HPV negative.
conclusionThere is a strong association between HPV and conjunctival papilloma. The study presents the largest material of conjunctival papilloma investigated for HPV and the first investigation of HPV in normal conjunctival tissue. HPV types 6 and 11 are the most common HPV types in conjunctival papilloma. This also is the first report of HPV type 45 in conjunctival papilloma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.