ArticleThe Journal of biological chemistry2007
Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis.
Article in The Journal of biological chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Article
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- Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/β-catenin and AKT/GSK3β proliferative signaling.The Journal of biological chemistry · 2019Article
- Clinical trials for BET inhibitors run ahead of the science.Drug discovery today. Technologies · 2016Review
- Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.Molecular cancer · 2015Review
- Targeting TRAF3 Downstream Signaling Pathways in B cell Neoplasms.Journal of cancer science & therapy · 2015Article
- BRD4 inhibitor inhibits colorectal cancer growth and metastasis.International journal of molecular sciences · 2015Article
- Expression and function of a novel isoform of Sox5 in malignant B cells.Leukemia research · 2014Article
- The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis.Journal of leukocyte biology · 2014Article
- Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.The Journal of biological chemistry · 2013Article
- Identification of candidate B-lymphoma genes by cross-species gene expression profiling.PloS one · 2013Article
- High-dose infusional gemcitabine combined with busulfan and melphalan with autologous stem-cell transplantation in patients with refractory lymphoid malignancies.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2012Article
- Transforming growth factor β1 (TGF-β1) suppresses growth of B-cell lymphoma cells by p14(ARF)-dependent regulation of mutant p53.The Journal of biological chemistry · 2012Article
- BET domain co-regulators in obesity, inflammation and cancer.Nature reviews. Cancer · 2012Review
- Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers.Scientific reports · 2012Article
- Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation.Discovery medicine · 2010Review
- An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.FEBS letters · 2010Review
- Development of a malignancy-associated proteomic signature for diffuse large B-cell lymphoma.The American journal of pathology · 2009Article
- Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The dual bromodomain protein Brd2 is closely related to the basal transcription factor TAF(II)250, which is essential for cyclin A transactivation and mammalian cell cycle progression. In transgenic mice, constitutive lymphoid expression of Brd2 causes a malignancy most similar to human diffuse large B cell lymphoma. We compare the genome-wide transcriptional expression profiles of these lymphomas with those of proliferating and resting normal B cells. Transgenic tumors reproducibly show differential expression of a large number of genes important for cell cycle control and lymphocyte biology; expression patterns are either tumor-specific or proliferation-specific. Several of their human orthologs have been implicated in human lymphomagenesis. Others correlate with human disease survival time. BRD2 is underexpressed in some subtypes of human lymphoma and these subtypes display a number of similarities to the BRD2-mediated murine tumors. We illustrate with a high degree of detail that cancer is more than rampant cellular proliferation, but involves the additional transcriptional mobilization of many genes, some of them poorly characterized, which show a tumor-specific pattern of gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.