ReviewCardiovascular research2007
Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy.
Review in Cardiovascular research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Response to Letter to the Editors "Factors influencing serum uric acid levels and their impact on cardiovascular risk in pediatric chronic kidney disease".Pediatric nephrology (Berlin, Germany) · 2026Article
- Metaproteomics analysis of anaerobic digestion of food waste by the addition of calcium peroxide and magnetite.Applied and environmental microbiology · 2024Article
- Osthole Prevents Heart Damage Induced by Diet-Induced Metabolic Syndrome: Role of Fructokinase (KHK).Antioxidants (Basel, Switzerland) · 2023Article
- Hypertriglyceridemic waist phenotype is associated with left ventricular hypertrophy in Chinese hypertension patients.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Association between triglyceride glucose index and worsening heart failure in significant secondary mitral regurgitation following percutaneous coronary intervention.Cardiovascular diabetology · 2022Article
- Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life.Journal of feline medicine and surgery · 2021Article
- Association of diet with left ventricular wall thickness, troponin I and IGF-1 in cats with subclinical hypertrophic cardiomyopathy.Journal of veterinary internal medicine · 2020Article
- Dietary Fat and Sugar Differentially Affect β-Adrenergic Stimulation of Cardiac ERK and AKT Pathways in C57BL/6 Male Mice Subjected to High-Calorie Feeding.The Journal of nutrition · 2020Article
- Associations among echocardiography, cardiac biomarkers, insulin metabolism, morphology, and inflammation in cats with asymptomatic hypertrophic cardiomyopathy.Journal of veterinary internal medicine · 2020Article
- Hypercaloric diet models do not develop heart failure, but the excess sucrose promotes contractility dysfunction.PloS one · 2020Article
- Article
- Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Possibility of a New Therapeutic Strategy for Left Ventricular Dysfunction in Type 2 Diabetes.Journal of clinical medicine research · 2018Review
- High-fat Diet Promotes Cardiac Remodeling in an Experimental Model of Obesity.Arquivos brasileiros de cardiologia · 2015Article
- Insulin resistance and subclinical abnormalities of global and regional left ventricular function in patients with aortic valve sclerosis.Cardiovascular diabetology · 2014Observational
- Article
- Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis.Cardiovascular diabetology · 2013Article
- Dietary fat and heart failure: moving from lipotoxicity to lipoprotection.Circulation research · 2012Review
- Effects of insulin therapy on myocardial lipid content and cardiac geometry in patients with type-2 diabetes mellitus.PloS one · 2012Article
- Changes in myofilament proteins, but not Ca²⁺ regulation, are associated with a high-fat diet-induced improvement in contractile function in heart failure.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Currently, a high carbohydrate/low fat diet is recommended for patients with hypertension; however, the potentially important role that the composition of dietary fat and carbohydrate plays in hypertension and the development of pathological left ventricular hypertrophy (LVH) has not been well characterized. Recent studies demonstrate that LVH can also be triggered by activation of insulin signaling pathways, altered adipokine levels, or the activity of peroxisome proliferator-activated receptors (PPARs), suggesting that metabolic alterations play a role in the pathophysiology of LVH. Hypertensive patients with high plasma insulin or metabolic syndrome have a greater occurrence of LVH, which could be due to insulin activation of the serine-threonine kinase Akt and its downstream targets in the heart, resulting in cellular hypertrophy. PPARs also activate cardiac gene expression and growth and are stimulated by fatty acids and consumption of a high fat diet. Dietary intake of fats and carbohydrate and the resultant effects of plasma insulin, adipokine, and lipid concentrations may affect cardiomyocyte size and function, particularly in the setting of chronic hypertension. This review discusses potential mechanisms by which dietary carbohydrates and fats ca affect cardiac growth, metabolism, and function, mainly in the context of pressure overload-induced LVH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.