ArticleRespiratory research2006
Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient.
Article in Respiratory research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Novel gain-of-function mutation in dysferlin causes vesicle trafficking defect and IL-1 mediated autoinflammation.medRxiv : the preprint server for health sciences · 2026Article
- Beyond Killing: The Overlooked Contribution of Neutrophils to Tissue Repair.International journal of molecular sciences · 2025Review
- Heterogeneity of Lung Phagocytes and Clearance of Apoptotic Cells in Lung Injury and Repair.Seminars in respiratory and critical care medicine · 2025Review
- Neutrophil heterogeneity and plasticity: unveiling the multifaceted roles in health and disease.MedComm · 2025Review
- Giant phagocytes (Gφ) and neutrophil-macrophage hybrids in human carotid atherosclerotic plaques - An activated phenotype.Frontiers in immunology · 2023Article
- Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization.PLoS computational biology · 2019Article
- In Vivo Comparative Study on Acute and Sub-acute Biological Effects Induced by Ultrafine Particles of Different Anthropogenic Sources in BALB/c Mice.International journal of molecular sciences · 2019Article
- Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs.Frontiers in pharmacology · 2019Review
- Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro.Journal of visualized experiments : JoVE · 2017Article
- Macrophage defense mechanisms against intracellular bacteria.Immunological reviews · 2015Review
- Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages.Cell host & microbe · 2012Article
- A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Neutrophils and macrophages: the main partners of phagocyte cell systems.Frontiers in immunology · 2012Article
- Proinflammatory stimuli enhance phagocytosis of apoptotic cells by neutrophil granulocytes.TheScientificWorldJournal · 2011Article
- Neutrophil responses to injury or inflammation impair peripheral gustatory function.Neuroscience · 2010Article
- Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin.Journal of leukocyte biology · 2008Article
- Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications.Apoptosis : an international journal on programmed cell death · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of extensive apoptosis the normal clearance system may fail, resulting in extensive neutrophil secondary necrosis. The aim of this study was to explore the hypothesis that neutrophils, in areas of the lung with extensive cellular infiltration, contribute to clearance by phagocytosing apoptotic cells and/or cell debris derived from secondary necrosis.
methodsIntranasal lipopolysaccharide administration was used to induce lung inflammation in mice. The animals were sacrificed at seven time points following administration, bronchoalveolar lavage was performed and tissue samples obtained. Electron microscopy and histochemistry was used to assess neutrophil phagocytosis.
resultsElectron microscopic studies revealed that phagocytosing neutrophils was common, at 24 h after LPS administration almost 50% of the total number of neutrophils contained phagosomes, and the engulfed material was mainly derived from other neutrophils. Histochemistry on bronchoalvolar lavage cells further showed phagocytosing neutrophils to be frequently occurring.
conclusionNeutrophils are previously known to phagocytose invading pathogens and harmful particles. However, this study demonstrates that neutrophils are also able to engulf apoptotic neutrophils or cell debris resulting from secondary necrosis of neutrophils. Neutrophils may thereby contribute to clearance and resolution of inflammation, thus acting as a back up system in situations when the macrophage clearance system is insufficient and/or overwhelmed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.