ArticleMolecular cancer2006
Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer.
Article in Molecular cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
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- Detection of novel mitochondrial mutations in cytochrome C oxidase subunit 1 (COX1) in patients with familial adenomatous polyposis (FAP).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020Article
- Mitochondrial DNA, nuclear context, and the risk for carcinogenesis.Environmental and molecular mutagenesis · 2019Review
- HPV-Induced Field Cancerisation: Transformation of Adult Tissue Stem Cell Into Cancer Stem Cell.Frontiers in microbiology · 2018Article
- Integrated transcriptomic analysis of distance-related field cancerization in rectal cancer patients.Oncotarget · 2017Article
- MtDNA As a Cancer Marker: A Finally Closed Chapter?Current genomics · 2017Review
- Mitochondrial DNA Mutations in Grade II and III Glioma Cell Lines Are Associated with Significant Mitochondrial Dysfunction and Higher Oxidative Stress.Frontiers in physiology · 2017Article
- Mitochondrial variants in MT-CO2 and D-loop instability are involved in MUTYH-associated polyposis.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Mitochondrial DNA alterations in the progression of gastric carcinomas: unexplored issues and future research needs.World journal of gastroenterology · 2014Review
- Inflammatory pathways in the early steps of colorectal cancer development.World journal of gastroenterology · 2014Review
- Mitochondriome and cholangiocellular carcinoma.PloS one · 2014Article
- Frequent occurrence of mitochondrial DNA mutations in Barrett's metaplasia without the presence of dysplasia.PloS one · 2012Article
- Article
- Mutational hotspots in the mitochondrial D-loop region of cancerous and precancerous colorectal lesions in Egyptian patients.DNA and cell biology · 2011Article
- Mitochondrial subversion in cancer.Cancer prevention research (Philadelphia, Pa.) · 2011Review
- Mitochondrial-nuclear epistasis: implications for human aging and longevity.Ageing research reviews · 2011Review
- Potential pitfalls in MitoChip detected tumor-specific somatic mutations: a call for caution when interpreting patient data.BMC cancer · 2010Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSomatic mutations of mitochondrial DNA (mtDNA) are common in many human cancers. We have described an oligonucleotide microarray ("MitoChip") for rapid sequencing of the entire mitochondrial genome (Zhou et al, J Mol Diagn 2006), facilitating the analysis of mtDNA mutations in preneoplastic lesions. We examined 14 precancerous lesions, including seven Barrett esophagus biopsies, with or without associated dysplasia; four colorectal adenomas; and three inflammatory colitis-associated dysplasia specimens. In all cases, matched normal tissues from the corresponding site were obtained as germline control. MitoChip analysis was performed on DNA obtained from cryostat-embedded specimens.
resultsA total of 513,639 bases of mtDNA were sequenced in the 14 samples, with 490,224 bases (95.4%) bases assigned by the automated genotyping software. All preneoplastic lesions examined demonstrated at least one somatic mtDNA sequence alteration. Of the 100 somatic mtDNA alterations observed in the 14 cases, 27 were non-synonymous coding region mutations (i.e., resulting in an amino acid change), 36 were synonymous, and 37 involved non-coding mtDNA. Overall, somatic alterations most commonly involved the COI, ND4 and ND5 genes. Notably, somatic mtDNA alterations were observed in preneoplastic lesions of the gastrointestinal tract even in the absence of histopathologic evidence of dysplasia, suggesting that the mitochondrial genome is susceptible at the earliest stages of multistep cancer progression.
conclusionOur findings further substantiate the rationale for exploring the mitochondrial genome as a biomarker for the early diagnosis of cancer, and confirm the utility of a high-throughput array-based platform for this purpose from a clinical applicability standpoint.
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