ArticleBMC genomics2006
Systematic identification and integrative analysis of novel genes expressed specifically or predominantly in mouse epididymis.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Effect of C-Type Natriuretic Peptide (CNP) on Spermatozoa Maturation in Adult Rat Epididymis.Current issues in molecular biology · 2023Article
- Defensins: defenders of human reproductive health.Human reproduction update · 2023Review
- Current markers for infertility in men.JBRA assisted reproduction · 2021Article
- Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq.Cell discovery · 2021Article
- Declined expressing mRNA of beta-defensin 108 from epididymis is associated with decreased sperm motility in blue fox (Vulpes lagopus).BMC veterinary research · 2021Article
- Seasonal expressions of SPAG11A and androgen receptor in the epididymis of the wild ground squirrels (<em>Citellus dauricus</em> Brandt).European journal of histochemistry : EJH · 2020Article
- Epididymal approaches to male contraception.Basic and clinical andrology · 2018Review
- Radioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II α.Cancer biology & therapy · 2015Article
- Androgenic regulation of beta-defensins in the mouse epididymis.Reproductive biology and endocrinology : RB&E · 2014Article
- Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells.Cancer biology & therapy · 2012Article
- Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes.The Journal of biological chemistry · 2011Article
- Localization and androgen regulation of metastasis-associated protein 1 in mouse epididymis.PloS one · 2010Article
- An integrated approach for the systematic identification and characterization of heart-enriched genes with unknown functions.BMC genomics · 2009Article
- Beta-defensin 22 is a major component of the mouse sperm glycocalyx.Reproduction (Cambridge, England) · 2008Article
- Avian defensins.Veterinary immunology and immunopathology · 2008Review
- New insights into epididymal biology and function.Human reproduction updateReview
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaturation of spermatozoa, including development of motility and the ability to fertilize the oocyte, occurs during transit through the microenvironment of the epididymis. Comprehensive understanding of sperm maturation requires identification and characterization of unique genes expressed in the epididymis.
resultsWe systematically identified 32 novel genes with epididymis-specific or -predominant expression in the mouse epididymis UniGene library, containing 1505 gene-oriented transcript clusters, by in silico and in vitro analyses. The Northern blot analysis revealed various characteristics of the genes at the transcript level, such as expression level, size and the presence of isoform. We found that expression of the half of the genes is regulated by androgens. Further expression analyses demonstrated that the novel genes are region-specific and developmentally regulated. Computational analysis showed that 15 of the genes lack human orthologues, suggesting their implication in male reproduction unique to the mouse. A number of the novel genes are putative epididymal protease inhibitors or beta-defensins. We also found that six of the genes have secretory activity, indicating that they may interact with sperm and have functional roles in sperm maturation.
conclusionWe identified and characterized 32 novel epididymis-specific or -predominant genes by an integrative approach. Our study is unique in the aspect of systematic identification of novel epididymal genes and should be a firm basis for future investigation into molecular mechanisms underlying sperm maturation in the epididymis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.