Trial reportBJOG : an international journal of obstetrics and gynaecology2007
The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2 years.
Trial report in BJOG : an international journal of obstetrics and gynaecology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Pooled it
- Pre-eclampsia, eclampsia, and hypertension.BMJ clinical evidence · 2011Pooled it
- Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Pre-eclampsia, eclampsia, and hypertension.BMJ clinical evidence · 2008Pooled it
- Effects of multivitamin combined with magnesium sulfate versus magnesium sulfate alone on hemodynamics, coagulation, and maternal-infant outcomes in preeclampsia: a randomized controlled study.Journal of health, population, and nutrition · 2025Trial
- Magpie Trial in the UK: methods and additional data for women and children at 2 years following pregnancy complicated by pre-eclampsia.BMC pregnancy and childbirth · 2009Trial
- The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months.BJOG : an international journal of obstetrics and gynaecology · 2007Trial
- A randomized controlled trial of loading dose alone versus pritchard regimen of magnesium sulphate, for seizure prophylaxis in severe preeclampsia.Annals of African medicineTrial
- Magnesium: Hype and Health Benefits.Current nutrition reports · 2026Review
- Neuroprotective effects of caffeine, erythropoietin, magnesium sulfate, and thyroxine in preterm infants: a network meta-analysis.Translational pediatrics · 2025Article
- The Management of Preeclampsia: A Comprehensive Review of Current Practices and Future Directions.Cureus · 2024Review
- A follow up on the feasibility after national implementation of magnesium sulfate for neuroprotection prior to preterm birth.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Maternal antioxidant micronutrient deficiencies among pre-eclamptic women in Enugu, Nigeria: a cross-sectional analytical study.The Journal of international medical research · 2023Article
- Maternal mortality in Bangladesh: Who, when, why, and where? A national survey-based analysis.Journal of global health · 2023Article
- Does Antenatal MgSOGeburtshilfe und Frauenheilkunde · 2023Article
- Confidential enquiry into maternal deaths in the Netherlands, 2006-2018.Acta obstetricia et gynecologica Scandinavica · 2022Article
- Factors affecting use of magnesium sulphate for pre-eclampsia or eclampsia: a qualitative evidence synthesis.BJOG : an international journal of obstetrics and gynaecology · 2022Review
- Increased Risk of Meconium-Related Ileus in Extremely Premature Infants Exposed to Antenatal Magnesium Sulfate.Neonatology · 2022Article
- The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases.Biological trace element research · 2021Review
- Eclampsia.Journal of education & teaching in emergency medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
objectiveThe aim of this study was to assess long-term effects for women following the use of magnesium sulphate for pre-eclampsia.
designAssessment at 2-3 years after delivery for women recruited to the Magpie Trial (recruitment in 1998-2001, ISRCTN 86938761), which compared magnesium sulphate with placebo for pre-eclampsia.
settingFollow up after discharge from hospital at 125 centres in 19 countries across five continents. POPULATION: A total of 7927 women were randomised at the follow-up centres. Of these women, 2544 were not included for logistic reasons and 601 excluded (109 at a centre where <20% of women were contacted, 466 discharged without a surviving child and 26 opted out). Therefore, 4782 women were selected for follow-up, of whom 3375 (71%) were traced.
methodsQuestionnaire assessment was administered largely by post or in a dedicated clinic. Interview assessment of selected women was performed. Main outcome measures Death or serious morbidity potentially related to pre-eclampsia at follow up, other morbidity and use of health service resources.
resultsMedian time from delivery to follow up was 26 months (interquartile range 19-36). Fifty-eight of 1650 (3.5%) women allocated magnesium sulphate died or had serious morbidity potentially related to pre-eclampsia compared with 72 of 1725 (4.2%) women allocated placebo (relative risk 0.84, 95% CI 0.60-1.18).
conclusionsThe reduction in the risk of eclampsia following prophylaxis with magnesium sulphate was not associated with an excess of death or disability for the women after 2 years.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.