ArticleBritish journal of clinical pharmacology2007
Assessment of renal function in clinical practice at the bedside of burn patients.
Article in British journal of clinical pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Prevalence and Risk Factors for Augmented Renal Clearance in Neurocritical Ill Patients.Journal of clinical laboratory analysis · 2025Observational
- Beta-Lactam Antibiotic Concentrations and the Acquisition of Multi-Drug Resistant Bacteria in Critically Ill Patients.Life (Basel, Switzerland) · 2025Article
- Comparative Evaluation of Efficacy of Digital Device (Modified Urinometer) For Evaluating the Effective Urine Output pH and Color as Compared to The Conventional Urine Bag- A Pilot Study.Journal of pharmacy & bioallied sciences · 2025Article
- Augmented Renal Function in Burn Patients: Occurrence and Discordance With Commonly Used Methods to Assess Renal Function.Journal of burn care & research : official publication of the American Burn Association · 2023Article
- Augmented Renal Clearance in Patients with Acute Ischemic Stroke: A Prospective Observational Study.Neurocritical care · 2023Observational
- Burn Injury and Augmented Renal Clearance: A Case for Optimized Piperacillin-Tazobactam Dosing.Journal of burn care & research : official publication of the American Burn Association · 2023Article
- Population Pharmacokinetic Modeling and Simulations of Imipenem in Burn Patients With and Without Continuous Venovenous Hemofiltration in the Military Health System.Journal of clinical pharmacology · 2021Article
- Augmented Renal Clearance Following Traumatic Injury in Critically Ill Patients Requiring Nutrition Therapy.Nutrients · 2021Article
- Evaluation of the Accuracy of Standard Renal Function Equations in Critically Ill Patients with Subarachnoid Hemorrhage.Neurocritical care · 2020Observational
- After standard dosage of piperacillin plasma concentrations of drug are subtherapeutic in burn patients.Naunyn-Schmiedeberg's archives of pharmacology · 2019Observational
- Screening of patients with augmented renal clearance in ICU: taking into account the CKD-EPI equation, the age, and the cause of admission.Annals of intensive care · 2015Article
- Augmented Renal Clearance in Patients with Subarachnoid Hemorrhage.Neurocritical care · 2015Article
- Comparison of different equations to assess glomerular filtration in critically ill patients.Intensive care medicine · 2015Article
- Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?Critical care (London, England) · 2015Article
- Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds.Critical care (London, England) · 2014Observational
- Accuracy of the estimation of glomerular filtration rate within a population of critically ill patients.Journal of nephrology · 2014Observational
- Estimation of renal function in the intensive care unit: the covert concepts brought to light.Journal of intensive care · 2014Review
- Clinical implications of antibiotic pharmacokinetic principles in the critically ill.Intensive care medicine · 2013Review
- A comparison of CKD-EPI estimated glomerular filtration rate and measured creatinine clearance in recently admitted critically ill patients with normal plasma creatinine concentrations.BMC nephrology · 2013Article
- Augmented renal clearance in septic and traumatized patients with normal plasma creatinine concentrations: identifying at-risk patients.Critical care (London, England) · 2013Observational
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
what is already known about this subject* In burn patients it has been shown ([2]), that there is a correlation between the creatinine clearance (CL(CR)) and the clearance of inulin. * The CL(CR) has never been studied in burn patients who have normal serum creatinine. * The Robert, Kirkpatrick and sMDRD formulae have never been evaluated in burn patients. WHAT THIS STUDY ADDS: * Despite burn patients having normal serum creatinine concentrations, the study showed that there are large variations in CL(CR) which cannot be detected by single serum creatinine measurements, and which have important implications for drug therapy. * It showed that the formulae currently used to calculate creatinine clearance on the basis of serum creatinine are inadequate for use in burn patients, and they should be abandoned in favour of direct measurement from a 24 h urine collection.
aimsThe aim of this study was to evaluate whether the renal function of burn patients could be correctly assessed using a single serum creatinine measurement, within normal limits, and three prediction equations of glomerular filtration taking into account, serum creatinine, age, weight and sex.
methodsThis was a prospective study comprising 36 adult burn patients with a serum creatinine <120 micromol l(-1), within the second or third week following the burn injury. Renal function was assessed using serum creatinine, 24 h urinary CL(CR), and the Cockcroft-Gault, Robert, Kirkpatrick and simplified MDRD equations.
resultsDespite normal serum creatinine concentrations in all patients, a significant number had a decreased CL(CR). The urinary CL(CR) was <80 ml(-1) min(-1) 1.73 m(-2) in nine patients (25%), and <60 ml(-1) min(-1) 1.73 m(-2) in five patients (14%). Between the groups having a CL(CR) lower or greater than 80 ml(-1) min(-1) 1.73 m(-2) there were no differences in gender, burn indices, percentage of mechanically ventilated patients or length of hospital stay, but a difference in age. The highest CL(CR) (>140 ml(-1) min(-1) 1.73 m(-2)) was found in 13 patients younger than 40 years. Regression analysis, residual and Bland-Altman plots revealed that neither the Cockcroft-Gault, Robert, Kirkpatrick nor sMDRD equations were specific enough for the assessment of renal function.
conclusionsIn burn patients with normal serum creatinine during the hypermetabolic phase, serum creatinine and creatine based predictive equations are imprecise in assessing renal function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.