ArticleAnalytical chemistry2006
Maximizing DNA loading on a range of gold nanoparticle sizes.
Article in Analytical chemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
234 citing papers in PubMed, 1,185 citations in OpenAlex.
- Impact of Positively Charged Backbone Modifications on the Properties of Spherical Nucleic Acids.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- In Silico Pre-Screening as a Design-Assessment Tool for Gold Nanoparticle-Amplified DNA Displacement Assays: Identifying Sequence-Level Design Limitations Across Electrode and Magnetic-Bead Configurations.International journal of molecular sciences · 2026Article
- Enhancing Enzyme Activity Via Noncovalent Association with DNA-Functionalized Nanoparticles.JACS Au · 2026Article
- Plasmonic Nanocrevice-Gap Nanosnowman Particles Enabling Colocalization of Raman Reporters with Super-Localized Electric Fields for Highly Sensitive, Specific, and Quantitative Surface-Enhanced Raman Scattering Biosensing.Journal of the American Chemical Society · 2026Article
- Metal-Phenolic Coatings Enable Universal Design of Spherical Nucleic Acids.Angewandte Chemie (International ed. in English) · 2026Article
- Design of Spherical Nucleic Acids: From Fast Synthesis to Structural Engineering.Biomolecules · 2026Review
- Programmable Hierarchical Assembly of Atomically Precise Metal Nanoclusters Using Supra-Amphiphilic Nucleic Acids.JACS Au · 2026Article
- RNA detection on a microfluidic platform using Thyclotides.Sensors and actuators reports · 2026Article
- Biomarker-targeted functionalized magnetic nanoparticles: synthesis and aptamer conjugation optimization toward Alzheimer's disease biosensing.Nanoscale advances · 2026Article
- Comparative Materials-Level Evaluation of 3'- and 5'-Thiol DNA Aptamer Conjugation on Gold Nanospheres and Nanoflowers: Apparent DNA Loading Output, Morphology Retention, and Qualitative Salt-Challenge Response.Sensors (Basel, Switzerland) · 2026Article
- Morphology-guided deep learning for nanoparticle agglomeration diagnostic assays.Scientific reports · 2026Article
- Spherical Nucleic Acids: Turning Synthetic Advances and Fundamental Discovery into Translational Breakthroughs in Chemistry, Materials Development, Biology, and Medicine.Accounts of chemical research · 2026Article
- Design, Mechanisms, and Applications of DNA-Mediated Dynamically Reconfigurable Plasmonic Gold Nanostructures.Small methods · 2026Review
- DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Expression and purification of NS1 protein for designing a lateral flow assay-based aptamer-antibody.Scientific reports · 2025Article
- Fuel-Free Rolosense: Viral Sensing Using Diffusional Particle Tracking.ACS sensors · 2025Article
- Rapid and simple detection of HCV RNA: enhanced colorimetric RT-LAMP method using unmodified gold nanoparticles.BMC microbiology · 2025Article
- Chemotherapeutic Spherical Nucleic Acids.ACS nano · 2025Article
- Highly Sensitive and Quantitative Detection of microRNA-21 in Cells Using Bipedal DNA Walker-Based Ratiometric Fluorescent Sensor.Analytical chemistry · 2025Article
- Programming Defects and Cavities into Colloidal Crystals Engineered With DNA.Advanced materials (Deerfield Beach, Fla.) · 2025Article
174 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have investigated the variables that influence DNA coverage on gold nanoparticles. The effects of salt concentration, spacer composition, nanoparticle size, and degree of sonication have been evaluated. Maximum loading was obtained by salt aging the nanoparticles to approximately 0.7 M NaCl in the presence of DNA containing a poly(ethylene glycol) spacer. In addition, DNA loading was substantially increased by sonicating the nanoparticles during the surface loading process. Last, nanoparticles up to 250 nm in diameter were found have approximately 2 orders of magnitude higher DNA loading than smaller (13-30 nm) nanoparticles, a consequence of their larger surface area. Stable large particles are attractive for a variety of biodiagnostic assays.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.