ArticleJournal of the American Chemical Society2006
Quantitative real-time measurements of DNA hybridization with alkylated nonoxidized silicon nanowires in electrolyte solution.
Article in Journal of the American Chemical Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- A Review of Readout Circuit Schemes Using Silicon Nanowire Ion-Sensitive Field-Effect Transistors for pH-Sensing Applications.Biosensors · 2025Review
- Application of Silicon Nanowire Field Effect Transistor (SiNW-FET) Biosensor with High Sensitivity.Sensors (Basel, Switzerland) · 2023Review
- Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule Detection.Sensors (Basel, Switzerland) · 2023Article
- Redox Buffering Effects in Potentiometric Detection of DNA Using Thiol-Modified Gold Electrodes.ACS sensors · 2021Article
- Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer.Nature communications · 2021Article
- Nanowire-Enabled Bioelectronics.Nano today · 2021Article
- Functionalization and Characterization of Silicon Nanowires for Sensing Applications: A Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Raman Mapping of Biological Systems Interacting with a Disordered Nanostructured Surface: A Simple and Powerful Approach to the Label-Free Analysis of Single DNA Bases.Micromachines · 2021Article
- Novel Nanofluidic Cells Based on Nanowires and Nanotubes for Advanced Chemical and Bio-Sensing Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- A Novel Silicon Platform for Selective Isolation, Quantification, and Molecular Analysis of Small Extracellular Vesicles.International journal of nanomedicine · 2021Article
- Recent advances in bioelectronics chemistry.Chemical Society reviews · 2020Review
- VLSI Structures for DNA Sequencing-A Survey.Bioengineering (Basel, Switzerland) · 2020Review
- A review on nanomaterial-based field effect transistor technology for biomarker detection.Mikrochimica acta · 2019Review
- Dengue virus: a review on advances in detection and trends - from conventional methods to novel biosensors.Mikrochimica acta · 2019Review
- Selective Functionalization with PNA of Silicon Nanowires on Silicon Oxide Substrates.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- CMOS-Compatible Silicon Nanowire Field-Effect Transistor Biosensor: Technology Development toward Commercialization.Materials (Basel, Switzerland) · 2018Review
- Recent advances in nanowires-based field-effect transistors for biological sensor applications.Biosensors & bioelectronics · 2018Review
- Amplified Detection of the Aptamer-Vanillin Complex with the Use of Bsm DNA Polymerase.Sensors (Basel, Switzerland) · 2017Article
- Aptamer based vanillin sensor using an ion-sensitive field-effect transistor.Mikrochimica acta · 2017Article
- Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor.Nature communications · 2017Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The quantitative, real-time detection of single-stranded oligonucleotides with silicon nanowires (SiNWs) in physiologically relevant electrolyte solution is demonstrated. Debye screening of the hybridization event is circumvented by utilizing electrostatically adsorbed primary DNA on an amine-terminated NW surface. Two surface functionalization chemistries are compared: an amine-terminated siloxane monolayer on the native SiO2 surface of the SiNW, and an amine-terminated alkyl monolayer grown directly on a hydrogen-terminated SiNW surface. The SiNWs without the native oxide exhibit improved solution-gated field-effect transistor characteristics and a significantly enhanced sensitivity to single-stranded DNA detection, with an accompanying 2 orders of magnitude improvement in the dynamic range of sensing. A model for the detection of analyte by SiNW sensors is developed and utilized to extract DNA-binding kinetic parameters. Those values are directly compared with values obtained by the standard method of surface plasmon resonance (SPR) and demonstrated to be similar. The nanowires, however, are characterized by higher detection sensitivity. The implication is that SiNWs can be utilized to quantitate the solution-phase concentration of biomolecules at low concentrations. This work also demonstrates the importance of surface chemistry for optimizing biomolecular sensing with silicon nanowires.
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Registered trials
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