ReviewReviews in endocrine & metabolic disorders2006
Insulin resistance in children and adolescents.
Review in Reviews in endocrine & metabolic disorders, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effects of exercise training on insulin resistance in children and adolescents with overweight or obesity: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.Diabetes · 2011Pooled it
- Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity-A PREVIEW randomized clinical trial.Pediatric obesity · 2021Trial
- Policaptil Gel Retard significantly reduces body mass index and hyperinsulinism and may decrease the risk of type 2 diabetes mellitus (T2DM) in obese children and adolescents with family history of obesity and T2DM.Italian journal of pediatrics · 2015Trial
- The absence of insulin resistance in metabolic syndrome definition leads to underdiagnosing of metabolic risk in obese patients.European journal of pediatrics · 2012Trial
- Insulin resistance in obese children and adolescents: from mechanisms to screening and exercise intervention.Frontiers in pediatrics · 2026Review
- How Can Promoting Skeletal Muscle Health and Exercise in Children and Adolescents Prevent Insulin Resistance and Type 2 Diabetes?Life (Basel, Switzerland) · 2024Review
- Exercise improves body composition, physical fitness, and blood levels of C-peptide and IGF-1 in 11- to 12-year-old boys with obesity.Frontiers in physiology · 2024Article
- Nomogram model for the risk of insulin resistance in obese children and adolescents based on anthropomorphology and lipid derived indicators.BMC public health · 2023Article
- Data assimilation on mechanistic models of glucose metabolism predicts glycemic states in adolescents following bariatric surgery.Frontiers in physiology · 2022Article
- Resting and exercise metabolic characteristics in obese children with insulin resistance.Frontiers in physiology · 2022Article
- Cross-Sectional and Longitudinal Examination of Insulin Sensitivity and Secretion across Puberty among Non-Hispanic Black and White Children.Endocrinology and metabolism (Seoul, Korea) · 2020Observational
- Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study.Nutrition & diabetes · 2018Article
- Metabolic Profiles in Obese Children and Adolescents with Insulin Resistance.Open access Macedonian journal of medical sciences · 2018Article
- Differential effects of age and sex on insulin sensitivity and body composition in adolescent offspring of women with type 1 diabetes: results from the EPICOM study.Diabetologia · 2018Article
- Article
- Predictors of Insulin Resistance in Children versus Adolescents with Obesity.Journal of obesity · 2017Observational
- Insulin sensitivity and brain reward activation in overweight Hispanic girls: a pilot study.Pediatric obesity · 2015Article
- Dietary patterns and breakfast consumption in relation to insulin resistance in children. The Healthy Growth Study.Public health nutrition · 2014Article
- Daily sugar-sweetened beverage consumption and insulin resistance in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study.Public health nutrition · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IR is hypothesized to be the important pathophysiologic link between adiposity and future development of type 2 diabetes and cardiovascular disease. A variety of methods for measuring IR have been validated in children, from the gold-standard hyperinsulinemic euglycemic clamp, to simple fasting measures based on fasting insulin and glucose levels. Studies have shown that there are a number of important risk factors for IR in children, including adiposity and visceral adiposity, race/ethnicity, puberty, a family history of type 2 diabetes, sex, and being small for gestational age or prematurity. However, obesity represents the critical risk factor for IR in children. Greater than 50% of obese adolescents in the US have IR. Formal assessment of IR in obese children may represent an important strategy for improving the efficacy of pharmacologic therapy for weight loss and chronic disease prevention.
Indexed as
Identifiers
17165145What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.