ArticlePflugers Archiv : European journal of physiology2007
Developmental changes of chromaffin cell secretory response to hypoxia studied in thin adrenal slices.
Article in Pflugers Archiv : European journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hif-2α programs oxygen chemosensitivity in chromaffin cells.The Journal of clinical investigation · 2024Article
- Expression and function of mitochondrial inhibitor factor-1 and TASK channels in adrenal cells.Biochemical and biophysical research communications · 2023Article
- Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2α.Frontiers in physiology · 2020Review
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- Regulation of catecholamine release from the adrenal medulla is altered in deer mice (American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Striking parallels between carotid body glomus cell and adrenal chromaffin cell development.Developmental biology · 2018Article
- Hypoxia-regulated catecholamine secretion in chromaffin cells.Cell and tissue research · 2018Review
- L-type calcium channels in exocytosis and endocytosis of chromaffin cells.Pflugers Archiv : European journal of physiology · 2018Review
- Gene expression analyses reveal metabolic specifications in acute OThe Journal of physiology · 2017Article
- Article
- Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion.The Journal of physiology · 2016Article
- Tight mitochondrial control of calcium and exocytotic signals in chromaffin cells at embryonic life.Pflugers Archiv : European journal of physiology · 2015Article
- Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Chronic exposure of neonatal rat adrenomedullary chromaffin cells to opioids in vitro blunts both hypoxia and hypercapnia chemosensitivity.The Journal of physiology · 2013Article
- Functional chromaffin cell plasticity in response to stress: focus on nicotinic, gap junction, and voltage-gated Ca2+ channels.Journal of molecular neuroscience : MN · 2012Review
- Developmental and stress-induced remodeling of cell–cell communication in the adrenal medullary tissue.Cellular and molecular neurobiology · 2010Review
- Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells.American journal of physiology. Cell physiology · 2010Article
- Revisiting the stimulus-secretion coupling in the adrenal medulla: role of gap junction-mediated intercellular communication.Molecular neurobiology · 2009Review
- Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cells.Journal of neurophysiology · 2009Article
- Developmental change of T-type Ca2+ channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia.The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adrenomedullary chromaffin (AMC) cells are sensitive to hypoxia in the newborn, but whether this property is lost during postnatal maturation is a matter of controversy. We have developed a rat adrenal slice preparation that allows the study of neonatal and adult AMC cell sensitivity to hypoxia in almost optimal physiological conditions. Responses to secretagogues can be quantitatively and noninvasively monitored in intact cells by amperometry. We have found hypoxia "responsive" (R) and "non-responsive" AMC cells in both neonatal (P0-P8) and juvenile/adult (P12-P60) adrenal glands. However, in the neonate, the proportion of R cells and the magnitude of the response to hypoxia were larger than in the adult. This developmental change of hypoxia responsiveness did not seem to depend on a decrease of the AMC cell's excitability. Spontaneous secretory activity in slices from adult rats was even increased with respect to neonatal animals. The analysis of the secretory events suggests that changes in spike frequency, rather than in vesicle size, account for the increased basal secretion rate in adult AMC cells. Thus, we report a major, but not complete, loss of direct hypoxia sensitivity in adult AMC cells. The adrenal slice appears to be a valuable technique to study acute O(2) sensing and its modifications in pathophysiological states.
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