ArticleRNA (New York, N.Y.)2007
Autoregulation of GLD-2 cytoplasmic poly(A) polymerase.
Article in RNA (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.Molecular biology and evolution · 2023Article
- Auto-regulatory feedback by RNA-binding proteins.Journal of molecular cell biology · 2019Review
- Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity.RNA (New York, N.Y.) · 2016Article
- PIWI homologs mediate histone H4 mRNA localization to planarian chromatoid bodies.Development (Cambridge, England) · 2014Article
- Autoregulation of Musashi1 mRNA translation during Xenopus oocyte maturation.Molecular reproduction and development · 2012Article
- Translational control by changes in poly(A) tail length: recycling mRNAs.Nature structural & molecular biology · 2012Review
- ePAT: a simple method to tag adenylated RNA to measure poly(A)-tail length and other 3' RACE applications.RNA (New York, N.Y.) · 2012Article
- Time of day regulates subcellular trafficking, tripartite synaptic localization, and polyadenylation of the astrocytic Fabp7 mRNA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- To polyadenylate or to deadenylate: that is the question.Cell cycle (Georgetown, Tex.) · 2010Review
- GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Deadenylation of maternal mRNAs mediated by miR-427 in Xenopus laevis embryos.RNA (New York, N.Y.) · 2009Article
- Spatially restricted translation of the xCR1 mRNA in Xenopus embryos.Molecular and cellular biology · 2009Article
- GLD2 poly(A) polymerase is required for long-term memory.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- RNA-binding proteins and post-transcriptional gene regulation.FEBS letters · 2008Review
- Translational control by cytoplasmic polyadenylation in Xenopus oocytes.Biochimica et biophysica acta · 2008Review
- A family of poly(U) polymerases.RNA (New York, N.Y.) · 2007Article
- Specificity factors in cytoplasmic polyadenylation.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cytoplasmic polyadenylation regulates mRNA stability and translation and is required for early development and synaptic plasticity. The GLD-2 poly(A) polymerase catalyzes cytoplasmic polyadenylation in the germline of metazoa. Among vertebrates, the enzyme is encoded by two isoforms of mRNA that differ only in the length of their 3'-UTRs. Here we focus on regulation of vertebrate GLD-2 mRNA. We show that the 3'-UTR of GLD-2 mRNA elicits its own polyadenylation and translational activation during frog oocyte maturation. We identify the sequence elements responsible for repression and activation, and demonstrate that CPEB and PUF proteins likely mediate repression in the resting oocyte. Regulated polyadenylation of GLD-2 mRNA is conserved, as are the key regulatory elements. Poly(A) tails of GLD-2 mRNA increase in length in the brain in response to neuronal stimulation, suggesting that a comparable system exists in that tissue. We propose a positive feedback circuit in which translation of GLD-2 mRNA is stimulated by its polyadenylation, thereby reinforcing the switch to polyadenylate and activate batteries of mRNAs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.