ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2006
Metabolic abnormalities and risk for colorectal cancer in the physicians' health study.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 12 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Diabetes and Risks of Right-Sided and Left-Sided Colon Cancer: A Meta-Analysis of Prospective Cohorts.Frontiers in oncology · 2022Pooled it
- Metabolic syndrome and the risk of colorectal cancer: a systematic review and meta-analysis.International journal of colorectal disease · 2021Pooled it
- The association of Metabolic Syndrome and its Components with the Incidence and Survival of Colorectal Cancer: A Systematic Review and Meta-analysis.International journal of biological sciences · 2021Pooled it
- Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies.Scientific reports · 2019Pooled it
- The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis.Public health nutrition · 2015Pooled it
- Colorectal cancer association with metabolic syndrome and its components: a systematic review with meta-analysis.Endocrine · 2013Pooled it
- CARING (CAncer Risk and INsulin analoGues): the association of diabetes mellitus and cancer risk with focus on possible determinants - a systematic review and a meta-analysis.Current drug safety · 2013Pooled it
- The association between metabolic syndrome and colorectal neoplasm: systemic review and meta-analysis.Journal of clinical gastroenterology · 2013Pooled it
- Metabolic syndrome and risk of cancer: a systematic review and meta-analysis.Diabetes care · 2012Pooled it
- Diabetes mellitus is an independent risk factor for colorectal cancer.Digestive diseases and sciences · 2012Pooled it
- Is diabetes mellitus an independent risk factor for colon cancer and rectal cancer?The American journal of gastroenterology · 2011Pooled it
- Diabetes mellitus and incidence and mortality of colorectal cancer: a systematic review and meta-analysis of cohort studies.European journal of epidemiology · 2011Pooled it
- Colorectal adenomas and diabetes: implications for disease prevention.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2015Trial
- Components of metabolic syndrome and metachronous colorectal neoplasia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Trial
- Statin Initiation and Mortality After Colorectal Cancer Treatment.JAMA network open · 2026Article
- Methodological Limitations in Aspirin-FIT Screening Research.Journal of gastroenterology and hepatology · 2026Article
- Association Between Allostatic Load and Incident Colorectal Cancer-A Prospective Study in a Multiethnic Asian Population.Cancer medicine · 2026Article
- Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective Study.Cancer medicine · 2025Article
- Alcohol Use, Coronary Heart Disease and Hypertension Modify the Predictive Accuracy of Pre-Operative CEA for TNM Staging in Chinese Colorectal Cancer Patients.Cancer management and research · 2025Article
- Prevalence of traditional atherosclerotic risk factors in newly diagnosed colorectal and breast cancer patients.ARYA atherosclerosis · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundObesity and diabetes are established risk factors for colorectal cancer but have mainly been assessed independently. There are few data about whether the metabolic syndrome, which refers to a clustering of cardiovascular disease risk factors thought to be related to insulin resistance, including obesity, type 2 diabetes, hyperlipidemia, and hypertension, is associated with colorectal cancer risk.
methodsDuring and after the randomized trial of aspirin and beta-carotene, 22,071 healthy male physicians, initially ages 40 to 84 years, reported overweight (body mass index, >or=27 kg/m2), diabetes, elevated blood pressure (>or=130/85 mmHg or use of antihypertensive medication), hypercholesterolemia (>or=240 mg/dL or use of lipid-lowering medication), and occurrence of cancer on annual questionnaires. Adjusted relative risks (RR) and 95% confidence intervals (95% CI) for time-varying metabolic abnormalities and colorectal cancer were estimated using a multivariable proportional hazards model.
resultsDuring 369,966 person-years of follow-up (median, 19 years), 494 physicians developed colorectal cancer. With aging of the cohort, the prevalence of having two or more abnormalities increased from 13% to 35%. Overweight (RR, 1.4; 95% CI, 1.1-1.7) and diabetes (RR, 1.5; 95% CI, 1.1-2.0) were associated with increased risk for colorectal cancer, whereas elevated blood pressure (RR, 1.1; 95% CI, 0.9-1.3) and hypercholesterolemia (RR, 0.9; 95% CI, 0.7-1.1) were not. This model assessing metabolic abnormalities independently was more predictive for colorectal cancer than a model based on the number of abnormalities (each additional abnormality RR, 1.16; 95% CI, 1.05-1.29).
conclusionsOut of the markers of the metabolic syndrome assessed, overweight and diabetes are risk factors for colorectal cancer, whereas, in contrast to their role in cardiovascular disease, elevated blood pressure and hypercholesterolemia are not.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.