ReviewCritical care (London, England)2006
Oxygen uptake-to-delivery relationship: a way to assess adequate flow.
Review in Critical care (London, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Mixed venous O2 saturation and fluid responsiveness after cardiac or major vascular surgery.Journal of cardiothoracic surgery · 2013Trial
- Crossing the line: blood transfusion thresholds in ECMO.Critical care (London, England) · 2025Article
- Association between mixed venous oxygen saturation and serum uric acid levels in patients with heart failure.PloS one · 2025Article
- Bedside determination of microcirculatory oxygen delivery and uptake: a prospective observational clinical study for proof of principle.Scientific reports · 2021Article
- Biochemical markers for clinical monitoring of tissue perfusion.Molecular and cellular biochemistry · 2021Review
- Article
- Integrated evaluation of hemodynamics: a novel approach for the assessment and management of preterm infants with compromised systemic circulation.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Less Fluids and a More Physiological Approach.Turkish journal of anaesthesiology and reanimation · 2016Article
- Donor preoperative oxygen delivery and post-extubation hypoxia impact donation after circulatory death hypoxic cholangiopathy.World journal of gastroenterology · 2016Article
- Hemoglobin optimization and transfusion strategies in patients undergoing cardiac surgery.World journal of cardiology · 2015Article
- Assessment of global tissue perfusion and oxygenation in neonates and infants after open-heart surgery.Interactive cardiovascular and thoracic surgery · 2014Article
- Tissue ischemia microdialysis assessments following severe traumatic haemorrhagic shock: lactate/pyruvate ratio as a new resuscitation end point?BMC anesthesiology · 2014Observational
- Functional echocardiographic assessment of myocardial performance in anemic premature infants: a pilot study.Pediatric cardiology · 2012Article
- Clinical pathology of the shock syndromes.Journal of emergencies, trauma, and shock · 2011Article
- Hypoxia--implications for pharmaceutical developments.Sleep & breathing = Schlaf & Atmung · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive and noninvasive monitoring facilitates clinical evaluation when resuscitating patients with complex haemodynamic disorders. If the macrocirculation is to be stable, then it must adapt to blood flow or blood flow must be optimized. The objective of flow monitoring is to assist with matching observed oxygen consumption (VO2) to pathophysiological needs. If an adequate balance cannot be maintained then dysoxia occurs. In this review we propose a simple schema for global reasoning; we discuss the limitations of VO2 and arterial oxygen delivery (DaO2) assessment; and we address concerns about increasing DaO2 to supranormal values or targeting pre-established levels of DaO2, cardiac output, or mixed venous oxygen saturation. All of these haemodynamic variables are interrelated and limited by physiological and/or pathological processes. A unique global challenge, and one that is of great prognostic interest, is to achieve rapid matching between observed and needed VO2--no more and no less. However, measuring or calculating these two variables at the bedside remains difficult. In practice, we propose a distinction between three situations. Clinical and blood lactate clearance improvements can limit investigations in simple cases. Intermediate cases may be managed by continuous monitoring of VO2-related variables such as DaO2, cardiac output, or mixed venous oxygen saturation. In more complex cases, three methods can help to estimate the needed VO2 level: comparison with expected values from past physiological studies; analysis of the relationship between VO2 and oxygen delivery; and use of computer software to integrate the preceding two methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.