ArticleBreast cancer research : BCR2006
Analysis of Epstein-Barr virus reservoirs in paired blood and breast cancer primary biopsy specimens by real time PCR.
Article in Breast cancer research : BCR, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Cytomegalovirus and Epstein-Barr virus in breast cancer.PloS one · 2015Pooled it
- Pooled it
- Epstein-Barr virus and breast cancer: lack of evidence for an association in Iranian women.Pathology oncology research : POR · 2011Trial
- Association between Epstein-Barr Virus Gene Polymorphism and Breast Cancer Risk among Egyptian Females.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Breast cancer and cytomegalovirus.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020Review
- No detection of EBV, BKV and JCV in breast cancer tissue samples in Iran.BMC research notes · 2019Article
- Association of Epstein - Barr virus and breast cancer in Eritrea.Infectious agents and cancer · 2017Article
- Epstein-Barr virus infection and clinical outcome in breast cancer patients correlate with immune cell TNF-α/IFN-γ response.BMC cancer · 2014Article
- Association of Epstein-Barr virus infection and breast carcinoma.Archives of medical science : AMS · 2013Article
- An expanded myeloid derived suppressor cell population does not play a role in gammaherpesvirus-exacerbated breast cancer metastases.Infectious agents and cancer · 2012Article
- Exacerbated metastatic disease in a mouse mammary tumor model following latent gammaherpesvirus infection.Infectious agents and cancer · 2012Article
- Epstein-Barr virus, human papillomavirus and mouse mammary tumour virus as multiple viruses in breast cancer.PloS one · 2012Article
- Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53.Virology journal · 2011Article
- Epstein-Barr virus as a marker of biological aggressiveness in breast cancer.British journal of cancer · 2011Article
- Recent Advances on the Possible Neuroprotective Activities of Epstein-Barr Virus Oncogene BARF1 Protein in Chronic Inflammatory Disorders of Central Nervous System.Current neuropharmacology · 2010Article
- Association of Epstein Barr virus infection (EBV) with breast cancer in rural Indian women.PloS one · 2009Article
- The possible involvement of virus in breast cancer.Journal of cancer research and clinical oncology · 2009Review
- Clinical-translational approaches to the Nm23-H1 metastasis suppressor.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
introductionEpstein-Barr virus (EBV) is present in over 90% of the world's population. This infection is considered benign, even though in limited cases EBV is associated with infectious and neoplastic conditions. Over the past decade, the EBV association with breast cancer has been constantly debated. Adding to this clinical and biological uncertainty, different techniques gave contradictory results for the presence of EBV in breast carcinoma specimens. In this study, minor groove binding (MGB)-TaqMan real time PCR was used to detect the presence of EBV DNA in both peripheral blood and tumor samples of selected patients.
methodsPeripheral blood and breast carcinoma specimens from 24 patients were collected. DNA was extracted and then amplified by MGB-TaqMan real time PCR.
resultsOf 24 breast tumor specimens, 11 (46%) were positive for EBV DNA. Of these 11 breast tumor specimens, 7 (64%) were also positive for EBV DNA in the peripheral blood, while 4 (36%) were positive for EBV DNA in the tumor, but negative in the blood.
conclusionEBV was found at extremely low levels, with a mean of 0.00004 EBV genomes per cell (range 0.00014 to 0.00001 EBV genomes per cell). Furthermore, our finding of the presence of EBV in the tumor specimens coupled to the absence of detection of EBV genomic DNA in the peripheral blood is consistent with the epithelial nature of the virus. Because of the low levels of viral DNA in tumor tissue, further studies are needed to assess the biological input of EBV in breast cancer.
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