Evidence map›Paper›PMID 17163276›Full record

Trial reportClinical drug investigation2006

Relationship between the frequency of blood pressure self-measurement and blood pressure reduction with antihypertensive therapy : results of the OLMETEL (OLMEsartan TELemonitoring blood pressure) study.

Silke Ewald, Johannes vor dem Esche, Sakir Uen, Fabian Neikes, Hans Vetter, Thomas Mengden

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Clinical drug investigation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Systematic review of home telemonitoring for chronic diseases: the evidence base.Journal of the American Medical Informatics Association : JAMIA
    Pooled it
  3. Trial
  4. Trial
  5. Predicting measurement continuity in home blood pressure monitoring using machine learning.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  6. Article
  7. Review
  8. [Possibilities of telemedicine in arterial hypertension].Medizinische Klinik (Munich, Germany : 1983) · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Silke EwaldSankyo Pharma GmbH, Munich, Germany. silke_ewald@sankyo-pharma.com
Johannes vor dem Esche
Sakir Uen
Fabian Neikes
Hans Vetter
Thomas Mengden

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis subanalysis of the OLMETEL (OLMEsartan TELemonitoring blood pressure) study in patients with essential hypertension assessed the relationship between the frequency of blood pressure self-measurement (BPSM) and the response to blood pressure (BP)-lowering therapy with olmesartan medoxomil, and the number of BP readings per week necessary to detect a mean systolic or diastolic BP reduction > or =5mm Hg.

methodsA total of 53 patients with essential hypertension received treatment with olmesartan medoxomil 10, 20 or 40 mg daily for 12 weeks. BPSM was performed for the first 9 weeks using a TensioPhone TP2 device. Patients were instructed to measure BP at least twice daily (morning and evening).

resultsAfter the first 9 weeks of the 12-week treatment period, the extent of BP reduction correlated with the number of BPSMs. Systolic/diastolic BP reductions in patients with a 100% adherence to at least two BP measurements daily were -16.6/-8.0mm Hg compared with -0.2/-3.3mm Hg in patients with only a 75% adherence to at least one BP measurement daily. Obtaining five home BP readings per week resulted in a sensitivity of 94.8% and a specificity of 90.0% to detect a BP reduction of > or =5mm Hg.

conclusionPatients adhering to the instructions for BPSM (at least two measurements daily) had a better response to antihypertensive treatment with olmesartan medoxomil. Whether BPSM per se resulted in an improved adherence to therapy or whether the number of recordings was an indicator of already existing adherence remains to be determined. Obtaining at least five home BP readings per week was identified as the threshold for correctly predicting response to olmesartan medoxomil treatment.

Indexed as

AdultAgedAged, 80 and overAngiotensin II Type 1 Receptor BlockersAntihypertensive AgentsBlood PressureBlood Pressure Monitoring, AmbulatoryDose-Response Relationship, DrugDrug Administration ScheduleFemaleHumansHypertensionImidazolesMaleMiddle AgedOlmesartan MedoxomilAngiotensin II Type 1 Receptor BlockersAntihypertensive AgentsImidazolesOlmesartan MedoxomilTetrazoles

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.