ArticleBiological psychiatry2007
Neuropsychological functioning in bipolar disorder and schizophrenia.
Article in Biological psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.
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Who cites it
97 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state.Neuropsychology · 2009Pooled it
- A quantitative and qualitative review of neurocognitive performance in pediatric bipolar disorder.Journal of child and adolescent psychopharmacology · 2008Pooled it
- Improvements in negative symptoms and functional outcome after a new generation cognitive remediation program: a randomized controlled trial.Schizophrenia bulletin · 2014Trial
- Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial.The American journal of psychiatry · 2007Trial
- Cognitive impairment preceding the onset of the first psychosis episode in schizophrenia.Molecular psychiatry · 2026Review
- Prior Trial Effects on Working Memory in Schizophrenia, Bipolar Disorder, and Healthy Control Individuals.JAMA psychiatry · 2026Article
- Bipolar Disorder Psychosis Risk Predicts Cue Discrimination on the AX-Continuous Performance Task Paradigm.Bipolar disorders · 2026Article
- The association between psychotropic medications and cognitive functioning in bipolar disorder.International journal of bipolar disorders · 2026Article
- Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes.Schizophrenia bulletin · 2026Article
- Abnormalcerebral-limbic functional connectivity between bipolar mania and bipolar depression under resting state.Frontiers in psychiatry · 2026Article
- Efficient measurement of dynamic working memory.Memory & cognition · 2025Article
- Protein aggregation identified in olfactory neuronal cells is associated with cognitive impairments in a subset of living schizophrenia patients.Molecular psychiatry · 2025Article
- Genome-Transcriptome-Functional Connectivity-Cognition Link Differentiates Schizophrenia From Bipolar Disorder.Schizophrenia bulletin · 2022Article
- Alterations in white matter network dynamics in patients with schizophrenia and bipolar disorder.Human brain mapping · 2022Article
- A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance.Molecular psychiatry · 2022Article
- Deficits in generalized cognitive ability, visual sensorimotor function, and inhibitory control represent discrete domains of neurobehavioral deficit in psychotic disorders.Schizophrenia research · 2021Article
- Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder.Communications biology · 2021Article
- Remote Ecological Momentary Testing of Learning and Memory in Adults With Serious Mental Illness.Schizophrenia bulletin · 2021Article
- Transdiagnostic comparison of visual working memory capacity in bipolar disorder and schizophrenia.International journal of bipolar disorders · 2021Article
- Multimodal MRI assessment for first episode psychosis: A major change in the thalamus and an efficient stratification of a subgroup.Human brain mapping · 2021Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundSome patients with bipolar disorder (BD) demonstrate neuropsychological deficits even when stable. However, it remains unclear whether these differ qualitatively from those seen in schizophrenia (SZ).
methodsWe compared the nature and severity of cognitive deficits shown by 106 patients with SZ and 66 patients with BD to 316 healthy adults (NC). All participants completed a cognitive battery with 19 individual measures. After adjusting their test performance for age, sex, race, education, and estimated premorbid IQ, we derived regression-based T-scores for each measure and the six cognitive domains.
resultsBoth patient groups performed significantly worse than NCs on most (BD) or all (SZ) cognitive tests and domains. The resulting effect sizes ranged from .37 to 1.32 (mean=.97) across tests for SZ patients and from .23 to .87 (mean=.59) for BD patients. The Pearson correlation of these effect sizes was .71 (p<.001).
conclusionsPatients with bipolar disorder suffer from cognitive deficits that are milder but qualitatively similar to those of patients with schizophrenia. These findings support the notion that schizophrenia and bipolar disorder show greater phenotypic similarity in terms of the nature than severity of their neuropsychological deficits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.