ArticleJournal of molecular evolution2007
Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family.
Article in Journal of molecular evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions.Nature communications · 2024Article
- Uncovering the essential roles of glutamate carboxypeptidase 2 orthologs in Caenorhabditis elegans.Bioscience reports · 2024Article
- The influence of microbiota on ferroptosis in intestinal diseases.Gut microbes · 2023Review
- Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer Care.Cancers · 2023Article
- GCP III is not the "off-target" for urea-based PSMA ligands.European journal of nuclear medicine and molecular imaging · 2023Article
- Mechanisms and regulations of ferroptosis.Frontiers in immunology · 2023Review
- Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.Parasites & vectors · 2022Article
- Review
- Review
- Article
- Transferrin Receptor Targeted Cellular Delivery of Doxorubicin Via a Reduction-Responsive Peptide-Drug Conjugate.Pharmaceutical research · 2019Article
- Magnetoferritin: Process, Prospects, and Their Biomedical Applications.International journal of molecular sciences · 2019Review
- PET imaging in prostate cancer: focus on prostate-specific membrane antigen.Current topics in medicinal chemistry · 2013Review
- Integrative approach to pain genetics identifies pain sensitivity loci across diseases.PLoS computational biology · 2012Article
- GCPII imaging and cancer.Current medicinal chemistry · 2012Review
- Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.PLoS genetics · 2011Article
- A novel choline cotransporter sequestration compartment in cholinergic neurons revealed by selective endosomal ablation.Journal of neurochemistry · 2010Article
- Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.Journal of molecular biology · 2008Article
- Dysregulation of glutamate carboxypeptidase II in psychiatric disease.Schizophrenia research · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transferrin receptor family is represented by at least seven different homologous proteins in primates. Transferrin receptor (TfR1) is a type II membrane glycoprotein that, as a cell surface homodimer, binds iron-loaded transferrin as part of the process of iron transfer and uptake. Other family members include transferrin receptor 2 (TfR2), glutamate carboxypeptidase II (GCP2 or PSMA), N-acetylated alpha-linked acidic dipeptidase-like protein (NLDL), N-acetylated alpha-linked acidic dipeptidase 2 (NAALAD2), and prostate-specific membrane antigen-like protein (PMSAL/GCPIII). We compared 86 different sequences from 24 different species, from mammals to fungi. Through this comparison, we have identified several highly conserved residues specific to each family not previously associated with clinical mutations. The evolutionary history of the TfR/GCP2 family shows repeated episodes of duplications consistent with recent theories that nondispensable, slowly evolving genes are more likely to form multiple gene families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.