ArticleJournal of molecular evolution2007
Fine-scale crossover rate heterogeneity in Drosophila pseudoobscura.
Article in Journal of molecular evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- The Genetic Architecture of Recombination Rates is Polygenic and Differs Between the Sexes in Wild House Sparrows (Passer domesticus).Molecular biology and evolution · 2024Article
- Variation in fine-scale recombination rate in temperature-evolved Drosophila melanogaster populations in response to selection.G3 (Bethesda, Md.) · 2022Article
- Centromere-Proximal Meiotic Crossovers inGenetics · 2019Article
- DNA Motifs Are Not General Predictors of Recombination in Two Drosophila Sister Species.Genome biology and evolution · 2019Article
- Article
- Fine-Scale Crossover Rate Variation on the Caenorhabditis elegans X Chromosome.G3 (Bethesda, Md.) · 2016Article
- Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females.G3 (Bethesda, Md.) · 2016Article
- Article
- The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster.PLoS genetics · 2016Article
- Recombining without Hotspots: A Comprehensive Evolutionary Portrait of Recombination in Two Closely Related Species of Drosophila.Genome biology and evolution · 2015Article
- Evidence for stabilizing selection on codon usage in chromosomal rearrangements of Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2014Article
- Background selection as baseline for nucleotide variation across the Drosophila genome.PLoS genetics · 2014Article
- Evidence that natural selection on codon usage in Drosophila pseudoobscura varies across codons.G3 (Bethesda, Md.) · 2014Article
- High-resolution linkage map for two honeybee chromosomes: the hotspot quest.Molecular genetics and genomics : MGG · 2014Article
- Article
- Sources and structures of mitotic crossovers that arise when BLM helicase is absent in Drosophila.Genetics · 2014Article
- Variation in meiotic recombination frequencies between allelic transgenes inserted at different sites in the Drosophila melanogaster genome.G3 (Bethesda, Md.) · 2013Article
- Fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome.Genetics · 2013Article
- Article
- Fine scale analysis of crossover and non-crossover and detection of recombination sequence motifs in the honeybee (Apis mellifera).PloS one · 2012Article
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Authors and funding
3 authors.
Funding
Abstract
Broad-scale differences in crossover rate across the genome have been characterized in most genomes studied. Fine-scale differences, however, have only been examined in a few taxa, such as Arabidopsis, yeast, humans, and mice. No prior studies have directly looked for fine-scale recombination rate heterogeneity in Drosophila. We produced 370 Drosophila pseudoobscura containing a crossover event within the 2-megabase (MB) region between the genes yellow and white. We then examined 19 intervals within this region and determined where the crossovers occurred. We found that recombination events occur nonrandomly on a small scale and that mild "hotspots" of a few kilobases exist in Drosophila. Among the regions studied, recombination rates varied from 1.4 to 52 cM/MB. We also observed a trend toward high codon bias in regions of high recombination. Finally, we identified a significantly positive correlation between recombination rate and simple repeats, as well as the motif CACAC. These sequence features may contribute to broad-scale variation in crossover rate and, thus, shed light on features associated with crossover rate heterogeneity at a genome-wide scale.
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