Evidence map›Paper›PMID 17160002›Full record

ReviewNature reviews. Microbiology2007

Advances in combating fungal diseases: vaccines on the threshold.

Jim E Cutler, George S Deepe, Bruce S Klein

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. The Pathogenesis ofPolish journal of microbiology · 2021
    Review
  12. Review
  13. Advances in Fungal Peptide Vaccines.Journal of fungi (Basel, Switzerland) · 2020
    Review
  14. Interaction ofJournal of tropical medicine · 2020
    Article
  15. A Heat-KilledmBio · 2019
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jim E CutlerDepartment of Pediatrics and Microbiology, Louisiana State University Health Sciences, and Research Institute for Children at Children's Hospital, New Orleans, Louisiana, 70118 USA. jcutler@chnola-research.org
George S Deepe
Bruce S Klein

Funding

PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUMR01AI034361 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 1993 to 2007
$2.5M
T CELL RECEPTOR USAGE IN PULMONARY HISTOPLASMOSISR37AI042747 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 1997 to 2006
$2.2M
NIAID NIH HHS R01 AI034361NIAID NIH HHS R37 AI042747
6 · The paper itself

Abstract

The dramatic increase in fungal diseases in recent years can be attributed to the increased aggressiveness of medical therapy and other human activities. Immunosuppressed patients are at risk of contracting fungal diseases in healthcare settings and from natural environments. Increased prescribing of antifungals has led to the emergence of resistant fungi, resulting in treatment challenges. These concerns, together with the elucidation of the mechanisms of protective immunity against fungal diseases, have renewed interest in the development of vaccines against the mycoses. Most research has used murine models of human disease and, as we review in this article, the knowledge gained from these studies has advanced to the point where the development of vaccines targeting human fungal pathogens is now a realistic and achievable goal.

Indexed as

Fungal VaccinesAnimalsAntibodies, FungalAntigens, FungalDisease Models, AnimalHumansImmunity, CellularImmunity, InnateMiceMycosesT-LymphocytesAntibodies, FungalAntigens, FungalFungal Vaccines

Identifiers

PMID17160002
PMCPMC2214303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.