ArticleEukaryotic cell2007
Two-component response regulators Ssk1p and Skn7p additively regulate high-osmolarity adaptation and fungicide sensitivity in Cochliobolus heterostrophus.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 62 citations in OpenAlex.
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- Homeobox transcription factor BmHox7 is required for sexual reproduction, but not for appressorial development and pathogenicity inMycoscience · 2025Article
- Dual regulation of appressorium development in the maize pathogenMycoscience · 2025Article
- The response regulator Skn7 of Aspergillus fumigatus is essential for the antifungal effect of fludioxonil.Scientific reports · 2021Article
- Downregulation of theFrontiers in fungal biology · 2021Article
- Involvement of a Response Regulator VdSsk1 in Stress Response, Melanin Biosynthesis and Full Virulence inFrontiers in microbiology · 2019Article
- SakA and MpkC Stress MAPKs Show Opposite and Common Functions During Stress Responses and Development inFrontiers in microbiology · 2018Article
- Dissecting the role of histidine kinase and HOG1 mitogen-activated protein kinase signalling in stress tolerance and pathogenicity of Parastagonospora nodorum on wheat.Microbiology (Reading, England) · 2016Article
- Plant phenolic compounds and oxidative stress: integrated signals in fungal-plant interactions.Current genetics · 2015Review
- The response regulator BcSkn7 is required for vegetative differentiation and adaptation to oxidative and osmotic stresses in Botrytis cinerea.Molecular plant pathology · 2015Article
- Genome and transcriptome analysis of the fungal pathogen Fusarium oxysporum f. sp. cubense causing banana vascular wilt disease.PloS one · 2014Article
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- The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans.Archives of microbiology · 2012Article
- Stress Response and Pathogenicity of the Necrotrophic Fungal Pathogen Alternaria alternata.Scientifica · 2012Review
- Involvement of a putative response regulator FgRrg-1 in osmotic stress response, fungicide resistance and virulence in Fusarium graminearum.Molecular plant pathology · 2011Article
- Characterization of the conserved phosphorylation site in the Aspergillus nidulans response regulator SrrA.Current genetics · 2011Article
- Fungal Skn7 stress responses and their relationship to virulence.Eukaryotic cell · 2011Review
- Article
- A copper-transporting ATPase BcCCC2 is necessary for pathogenicity of Botrytis cinerea.Molecular genetics and genomics : MGG · 2010Article
- The two-component histidine kinase Fhk1 controls stress adaptation and virulence of Fusarium oxysporum.Molecular plant pathology · 2010Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamentous ascomycetous fungi possess many histidine kinases and two conserved response regulators, Ssk1p and Skn7p, in their two-component signaling systems. We previously reported that the fungus unique group III histidine kinase regulates high-osmolarity adaptation and iprodione/fludioxonil fungicide sensitivity by controlling the phosphorylation of Hog1-type mitogen-activated protein kinase (MAPK) in filamentous ascomycetes. Here, we have characterized the response regulator genes ChSsk1 and ChSkn7 in the southern corn leaf blight fungus Cochliobolus heterostrophus. Both ChSsk1- and ChSkn7-disrupted mutants showed little sensitivity to high-osmolarity stress and moderate resistance to the iprodione/fludioxonil fungicides. The phosphorylation of Hog1-type MAPK BmHog1p induced by high-osmolarity stress and fungicide treatments was only regulated by ChSsk1p, indicating that ChSkn7p has roles in high-osmolarity adaptation and fungicide sensitivity that are independent from the activation of BmHog1p. The Chssk1 Chskn7 double mutants clearly showed higher sensitivity to osmolar stress and higher resistance to fungicides than the single mutants. The dose responses of the double mutants fit well with those of the group III histidine kinase-deficient strain. These results suggest that in filamentous ascomycetes, the Ssk1- and Skn7-type response regulators control high-osmolarity adaptation and fungicide sensitivity additively with differential mechanisms under the regulation of the group III histidine kinase. This study provides evidence that filamentous fungi have a unique two-component signaling system that is different from that of yeast and is responsible for high-osmolarity adaptation and fungicide sensitivity.
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