ArticleRNA (New York, N.Y.)2007
Identification of a sequence motif critical for editing of a tobacco chloroplast transcript.
Article in RNA (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Conservation of the moss RNA editing factor PPR78 despite the loss of its known cytidine-to-uridine editing sites is explained by a hidden extra target.The Plant cell · 2024Article
- A ribonuclease activity linked to DYW1 in vitro is inhibited by RIP/MORF proteins.Scientific reports · 2023Article
- A plant pentatricopeptide repeat protein with a DYW-deaminase domain is sufficient for catalyzing C-to-U RNA editingThe Journal of biological chemistry · 2020Article
- Stable native RIP9 complexes associate with C-to-U RNA editing activity, PPRs, RIPs, OZ1, ORRM1 and ISE2.The Plant journal : for cell and molecular biology · 2019Article
- A novel tetratricopeptide repeat protein, WHITE TO GREEN1, is required for early chloroplast development and affects RNA editing in chloroplasts.Journal of experimental botany · 2017Article
- An Organelle RNA Recognition Motif Protein Is Required for Photosystem II SubunitPlant physiology · 2017Article
- Organelle RNA recognition motif-containing (ORRM) proteins are plastid and mitochondrial editing factors in Arabidopsis.Plant signaling & behavior · 2016Article
- RNA Recognition Motif-Containing Protein ORRM4 Broadly Affects Mitochondrial RNA Editing and Impacts Plant Development and Flowering.Plant physiology · 2016Article
- Two RNA recognition motif-containing proteins are plant mitochondrial editing factors.Nucleic acids research · 2015Article
- A zinc finger motif-containing protein is essential for chloroplast RNA editing.PLoS genetics · 2015Article
- Cytidine deaminase motifs within the DYW domain of two pentatricopeptide repeat-containing proteins are required for site-specific chloroplast RNA editing.The Journal of biological chemistry · 2015Article
- Review
- Identification of two pentatricopeptide repeat genes required for RNA editing and zinc binding by C-terminal cytidine deaminase-like domains.The Journal of biological chemistry · 2013Article
- An RNA recognition motif-containing protein is required for plastid RNA editing in Arabidopsis and maize.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Molecular evolution of pentatricopeptide repeat genes reveals truncation in species lacking an editing target and structural domains under distinct selective pressures.BMC evolutionary biology · 2012Article
- RNA editing of nuclear transcripts in Arabidopsis thaliana.BMC genomics · 2010Article
- A comparative genomics approach identifies a PPR-DYW protein that is essential for C-to-U editing of the Arabidopsis chloroplast accD transcript.RNA (New York, N.Y.) · 2009Article
- CURE-Chloroplast: a chloroplast C-to-U RNA editing predictor for seed plants.BMC bioinformatics · 2009Article
- High conservation of a 5' element required for RNA editing of a C target in chloroplast psbE transcripts.Journal of molecular evolution · 2008Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleotides are specifically and efficiently targeted for modification from C to U within transcripts of chloroplasts in higher plants. Although the enzymatic apparatus responsible for altering C to U has not been identified, the sequences surrounding editing sites are known to contain information essential for efficient editing. We set out to determine the nucleotides that are critical for editing of a particular C, NTpsbE C214, in chloroplast transcripts in tobacco. Assay of editing of substrates with different lengths of 5' and 3' sequence around the target C was carried out to delimit the region of sequence critical for editing in vitro. Mutated substrates were then constructed with an altered nucleotide at each position within the previously defined region around NTpsbE C214. In individual nucleotides, both 5' and 3' of the edited nucleotide were found to be important for editing. The sequence GCCGUU, which occurs 5' of the editing site, was discovered to be critical for editing. Editing substrates mutated to alter the distance between the GCCGUU sequence and NTpsbE C214 resulted in the generation of a new editing target, the 3' adjacent nucleotide. These data are consistent with a model in which the selection of the C target for editing is determined by its distance from a crucial 5' sequence.
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