ArticleJournal of medical genetics2007
Y-chromosome haplogroups and susceptibility to azoospermia factor c microdeletion in an Italian population.
Article in Journal of medical genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Prevalence and clinical considerations of Y chromosome microdeletions in azoospermic and oligozoopsermic infertile men from Al Madinah Al Munawarah, Saudi Arabia.Saudi medical journal · 2025Article
- Bridging the Gap between AZF Microdeletions and Karyotype: Twelve Years' Experience of an Infertility Center.The world journal of men's health · 2023Article
- High incidences of chromosomal aberrations and Y chromosome micro-deletions as prominent causes for recurrent pregnancy losses in highly ethnic and consanguineous population.Archives of gynecology and obstetrics · 2022Article
- Associations between male infertility and ancestry in South Americans: a case control study.BMC medical genetics · 2017Article
- Spermatogenic failure and the Y chromosome.Human genetics · 2017Review
- Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia.Scientific reports · 2016Article
- Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health.Clinical epigenetics · 2015Review
- Greater prevalence of Y chromosome Q1a3a haplogroup in Y-microdeleted Chilean men: a case-control study.Journal of assisted reproduction and genetics · 2013Article
- Y chromosome microdeletions in infertile men: prevalence, phenotypes and screening markers for the Indian population.Journal of assisted reproduction and genetics · 2013Article
- The low frequency of Y chromosome microdeletions in subfertile males in a Sinhalese population of Sri Lanka.Indian journal of human genetics · 2012Article
- Screening for Y-chromosome microdeletions in a population of infertile males in the Gaza Strip.Journal of experimental & clinical assisted reproduction · 2009Article
- An evolutionary perspective on Y-chromosomal variation and male infertility.International journal of andrology · 2008Review
- Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertility.Journal of medical genetics · 2007Article
- Examination of Y-Chromosomal Microdeletions and Partial Microdeletions in Idiopathic Infertility in East Hungarian Patients.Journal of human reproductive sciencesArticle
- The AZFc region of the Y chromosome: at the crossroads between genetic diversity and male infertility.Human reproduction updateReview
- Microdeletion of Y chromosome as a cause of recurrent pregnancy loss.Journal of human reproductive sciencesArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA limited number of studies aimed at investigating the possible association of Y-chromosome haplogroups with microdeletions of the azoospermia factors (AZFs) or with particular infertile phenotypes, but definitive conclusions have not been attained. The main confounding elements in these association studies are the small sample sizes and the lack of homogeneity in the geographical origin of studied populations, affecting, respectively, the statistical power and the haplogroup distribution. MATERIALS AND
methodsTo assess whether some Y-chromosome haplogroups are predisposing to, or protecting against, azoospermia factor c (AZFc; b2/b4) deletions, 31 north Italian patients carrying the AZFc b2/b4 microdeletion were characterised for 8 Y-chromosome haplogroups, and compared with the haplogroup frequency shown by a north Italian population without the microdeletion (n = 93). RESULTS AND DISCUSSION: A significant difference was observed between the two populations, patients with microdeletions showing a higher frequency of the E haplogroup (29.3% vs 9.7%, p<0.01). The geographical homogeneity of the microdeleted samples and of the control population, controlled at microgeographical level, allows the possibility that the geographical structure of the Y genetic variability has affected our results to be excluded.
conclusionThus, it is concluded that in the north Italian population Y-chromosome background affects the occurrence of AZFc b2/b4 deletions.
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