ArticleBiophysical journal2007
Entropy and barrier-controlled fluctuations determine conformational viscoelasticity of single biomolecules.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 55 citations in OpenAlex.
- Effects of Proline on Internal Friction in Simulated Folding Dynamics of Several Alanine-Based α-Helical Peptides.The journal of physical chemistry. B · 2024Article
- Analytical Approaches for Deriving Friction Coefficients for Selected α-Helical Peptides Based Entirely on Molecular Dynamics Simulations.The journal of physical chemistry. B · 2022Article
- Pectin biopolymer mechanics and microstructure associated with polysaccharide phase transitions.Journal of biomedical materials research. Part A · 2020Article
- Conformational entropy of a single peptide controlled under force governs protease recognition and catalysis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Unwinding and rewinding the nucleosome inner turn: force dependence of the kinetic rate constants.Physical review. E, Statistical, nonlinear, and soft matter physics · 2013Article
- Marine polysaccharides in microencapsulation and application to aquaculture: "from sea to sea".Marine drugs · 2011Review
- Conformational dynamics and internal friction in homopolymer globules: equilibrium vs. non-equilibrium simulations.The European physical journal. E, Soft matter · 2011Article
- Deconvolution of dynamic mechanical networks.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Dynamics of the coiled-coil unfolding transition of myosin rod probed by dissipation force spectrum.Biophysical journal · 2010Article
- The elastic properties of the Cryptococcus neoformans capsule.Biophysical journal · 2009Article
- The effect of temperature on mechanical resistance of the native and intermediate states of I27.Biophysical journal · 2008Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological macromolecules have complex and nontrivial energy landscapes, endowing them with a unique conformational adaptability and diversity in function. Hence, understanding the processes of elasticity and dissipation at the nanoscale is important to molecular biology and emerging fields such as nanotechnology. Here we analyze single molecule fluctuations in an atomic force microscope, using a generic model of biopolymer viscoelasticity that includes local "internal" conformational dissipation. Comparing two biopolymers, dextran and cellulose (polysaccharides with and without local bistable transitions), demonstrates that signatures of simple conformational change are minima in both the elastic and internal friction constants around a characteristic force. A novel analysis of dynamics on a bistable energy landscape provides a simple explanation: an elasticity driven by the entropy, and friction by a barrier-controlled hopping time of populations between states, which is surprisingly distinct to the well-known relaxation time. This nonequilibrium microscopic analysis thus provides a means of quantifying new dynamical features of the energy landscape of the glucopyranose ring, revealing an unexpected underlying roughness and information on the shape of the barrier of the chair-boat transition in dextran. The results presented herein provide a basis toward probing the viscoelasticity of macromolecular conformational transitions on more complex energy landscapes, such as during protein folding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.