ArticleJournal of neurology, neurosurgery, and psychiatry2007
Accuracy of single-photon emission computed tomography in differentiating frontotemporal dementia from Alzheimer's disease.
Article in Journal of neurology, neurosurgery, and psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Regional cerebral blood flow single photon emission computed tomography for detection of Frontotemporal dementia in people with suspected dementia.The Cochrane database of systematic reviews · 2015Pooled it
- Systematic review of the diagnostic utility of SPECT imaging in dementia.European archives of psychiatry and clinical neuroscience · 2013Pooled it
- Sink-index: a network-based EEG marker for frontotemporal dementia and Alzheimer's disease.Brain communications · 2025Article
- Regional cerebral blood flow in behavioral variant of FTD: hypoperfusion patterns and clinical associations.Acta neurologica Belgica · 2024Article
- The Legacy of the TTASAAN Report-Premature Conclusions and Forgotten Promises: A Review of Policy and Practice Part I.Frontiers in neurology · 2021Review
- Biomarkers and Precision Medicine in Alzheimer's Disease.Advances in experimental medicine and biology · 2021Article
- Application of Artificial Neural Networks to Identify Alzheimer's Disease Using Cerebral Perfusion SPECT Data.International journal of environmental research and public health · 2019Article
- Dual-phase [18F]florbetapir in frontotemporal dementia.European journal of nuclear medicine and molecular imaging · 2019Article
- Using simultaneous PET/MRI to compare the accuracy of diagnosing frontotemporal dementia by arterial spin labelling MRI and FDG-PET.NeuroImage. Clinical · 2018Article
- Usefulness of EEG Techniques in Distinguishing Frontotemporal Dementia from Alzheimer's Disease and Other Dementias.Disease markers · 2018Review
- Frontotemporal Dementias.Continuum (Minneapolis, Minn.) · 2016Review
- Emerging biomarkers in cognition.Clinics in geriatric medicine · 2013Review
- Clinical applications of neuroimaging in patients with Alzheimer's disease: a review from the Fourth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012.Alzheimer's research & therapy · 2013Article
- Distinct patterns of medial temporal impairment in degenerative dementia: a brain SPECT perfusion study in Alzheimer's disease and frontotemporal dementia.European journal of nuclear medicine and molecular imaging · 2013Article
- Using the revised diagnostic criteria for frontotemporal dementia in India: evidence of an advanced and florid disease.PloS one · 2013Article
- Clinical phenotypes and genetic biomarkers of FTLD.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
- C9ORF72 repeat expansions and other FTD gene mutations in a clinical AD patient series from Mayo Clinic.American journal of neurodegenerative disease · 2012Article
- Biomarkers in frontotemporal lobar degenerations--progress and challenges.Progress in neurobiology · 2011Review
- The corticobasal syndrome-Alzheimer's disease conundrum.Expert review of neurotherapeutics · 2011Review
- Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia.Brain : a journal of neurology · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlzheimer's disease (AD) and frontotemporal dementia (FTD) are the commonest causes of presenile dementia. In the absence of a biological marker, diagnosis is reliant on clinical evaluation. Confirmation is often sought from neuroimaging, including single-photon emission computed tomography (SPECT). Most previous SPECT studies lack pathological validation.
aimTo examine the accuracy of SPECT in differentiating FTD from AD in patients with subsequent pathological confirmation.
methodsTechnetium-99-labelled hexamethyl propylene amine oxime SPECT images obtained at initial evaluation in 25 pathologically confirmed cases of FTD were examined. These images were visually rated by an experienced blinded nuclear medicine consultant and compared with those of 31 patients with AD, also with pathological validation.
resultsA reduction in frontal cerebral blood flow (CBF) was more common in FTD and was of diagnostic value (sensitivity 0.8, specificity 0.65 and likelihood ratio (LR) 2.25; 95% CI 1.35 to 3.77). A pattern of bilateral frontal CBF reduction without the presence of associated bilateral parietal CBF change is diagnostically more accurate (sensitivity 0.80, specificity 0.81 and +LR 4.13, 95% CI 1.96 to 8.71). Diagnostic categorisation (FTD or AD) on the basis of SPECT alone was less accurate than clinical diagnosis (based on neurology and detailed neuropsychological evaluation). One patient with FTD was initially clinically misdiagnosed as AD, owing to the lack of availability of full neuropsychological assessment. However, SPECT correctly diagnosed this patient, providing a diagnostic gain of 4%.
conclusionTechnetium-99-labelled hexamethyl propylene amine oxime SPECT CBF patterns provide valuable information in the diagnosis of FTD and AD. These data can be better used as an adjunct to clinical diagnosis if pathology is to be correctly predicted in life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.